Physical properties of the bacterial outer membrane.

Physical properties of the bacterial outer membrane.
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DOI:
10.1038/s41579-021-00638-0
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发表时间:
2022-04
期刊:
Nature reviews. Microbiology
影响因子:
--
通讯作者:
Huang KC
Huang KC
中科院分区:
其他
文献类型:
--
作者:
Sun J;Rutherford ST;Silhavy TJ;Huang KC

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革兰氏阴性菌外膜(OM)作为渗透屏障的能力长期以来一直受到重视,但最近的研究发现OM在细胞生理学和活力方面具有更广泛和更广泛的作用。由于微流体和显微镜的最新发展,OM的结构、流变学和机械特性在多个尺度上变得越来越明显。在这篇综述中,我们讨论了最近的实验和计算研究,揭示了关键的分子因素和相互作用,引起的空间组织,有限的扩散率和应力承载能力的OM。这些物理特性表明细胞结构和生理之间的广泛联系,我们探讨了未来的前景,进一步阐明OM建设对细胞的健身和生存的影响。
The ability of the Gram-negative outer membrane (OM) to act as a permeability barrier has long been appreciated, but recent studies have uncovered a more expansive and versatile role for the OM in cellular physiology and viability. Due to recent developments in microfluidics and microscopy, the structural, rheological, and mechanical properties of the OM are becoming apparent across multiple scales. In this review, we discuss recent experimental and computational studies that have revealed key molecular factors and interactions that give rise to the spatial organization, limited diffusivity, and stress-bearing capacity of the OM. These physical properties suggest broad connections between cellular structure and physiology, and we explore future prospects for further elucidation of the implications of OM construction on cellular fitness and survival.
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