Modelling multiple laser pulses for port wine stain treatment
Modelling multiple laser pulses for port wine stain treatment
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DOI：
10.1088/0031-9155/45/12/403
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发表时间：
2000-12-01
影响因子：
3.5
通讯作者：
Nelson, JS
中科院分区：
文献类型：
--
作者：
Verkruysse, W;van Gemert, MJC;Nelson, JS
许多鲜红斑痣 (PWS) 仍然对脉冲染料激光治疗有抵抗力。然而，轶事信息表明，多次脉冲激光照射可以改善患者的治疗效果。我们在这篇文章中的目的是解释潜在的机制并估计 PWS 典型血管结构中多个脉冲可能产生的热效应。根据线性响应理论，两种热贡献的线性组合导致激光照射血管的温度总体升高：血液的直接光吸收和相邻血管的直接双边热传导。后者对目标容器中温度升高的贡献可能是显着的，特别是如果一些相邻容器非常接近，例如在目标容器的光学屏蔽的情况下，或者如果容器相对较远但数量很多。我们提出的证据表明，多脉冲激光照射目标是被其他血管光学屏蔽的血管。因此，它可能是增强 PWS 治疗对单脉冲染料激光治疗无效的病变的一种手段。
Many port wine stains (PWS) are still resistant to pulsed dye laser treatment. However, anecdotal information suggests that multiple pulse laser irradiation improves patient outcome. Our aims in this note are to explain the underlying mechanism and estimate the possible thermal effects of multiple pulses in vascular structures typical of PWS. Based on linear response theory, the linear combination of two thermal contributions is responsible for the total increase in temperature in laser irradiated blood vessels: direct light absorption by blood and direct bilateral thermal heat conduction from adjacent blood vessels. The latter contribution to the increase in temperature in the targeted vessel can be significant, particularly if some adjacent vessels are in close proximity, such as in cases of optical shielding of the targeted vessel, or if the vessels are relatively distant but many in number. We present evidence that multiple pulse laser irradiation targets blood vessels that are optically shielded by other vessels. Therefore, it may be a means of enhancing PWS therapy for lesions that fail to respond to single-pulse dye laser treatment.