CONGENER-SPECIFIC DETERMINATION OF POLYCHLORINATED-BIPHENYLS AND ORGANOCHLORINE PESTICIDES IN HUMAN-MILK FROM NORWEGIAN MOTHERS LIVING IN OSLO
CONGENER-SPECIFIC DETERMINATION OF POLYCHLORINATED-BIPHENYLS AND ORGANOCHLORINE PESTICIDES IN HUMAN-MILK FROM NORWEGIAN MOTHERS LIVING IN OSLO
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DOI：
10.1080/15287399409531870
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发表时间：
1994-06-01
期刊：
影响因子：
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通讯作者：
SKAARE, JU
中科院分区：
文献类型：
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作者：
JOHANSEN, HR;BECHER, G;SKAARE, JU
1991年在挪威奥斯陆市立医院采集了28位母亲的母乳样本，并分析了个别多氯联苯(PCB)同系物，IUPAC编号为28、74、99、101、105、114、118、128、138、141、153、156、157、170、180、194和206，以及选定的非邻位取代化合物IUPAC编号77、126和169。还测定了总滴滴涕(DDT及相关物质的浓度总和)、六氯苯(HCB)、环氧氯丹、异壬草胺和六六六(甲型六氯环己烷、乙型六氯环己烷和伽马型六氯环己烷的浓度总和)。人乳脂肪中总滴滴涕、六氯苯、环氧氯丹、反式甲草胺和总六氯环己烷的平均含量分别为338、41、9、19和36 ng/g，p‘-滴滴涕和β-六氯环己烷分别占总滴滴涕和总六六六的81%和93%。总多氯联苯的平均水平(20个单项同系物的平均浓度之和)为372 ng/g乳脂。总多氯联苯和多氯联苯-153之间有很好的相关性(r=0.97)。在挪威以前的母乳调查中使用填充柱法计算出的多氯联苯总量中，在毛细管柱上测定的多氯联苯总量占62-79%。与以前的结果比较表明，在过去的9年里，多氯联苯、六氯联苯和总滴滴涕的平均水平分别下降了70%、65%和75%。评估了个别多氯二苯并二恶英/多氯二苯并呋喃(挪威先前的研究)以及非和单邻位取代多氯联苯同系物对计算出的总毒性当量值的贡献，发现多氯联苯是母乳中四氯联苯当量的主要组成部分，多氯联苯-126是主要贡献者。
Human milk samples from 28 mothers at Oslo City Hospital, Norway, were collected in 1991 and analyzed for individual polychlorinated Diphenyl (PCB) congeners, IUPAC numbers 28, 74, 99, 101, 105, 114, 118, 128, 138, 141, 153, 156, 157, 170, 180, 194, and 206, plus selected non-ortho-substituted compounds, IUPAC numbers 77, 126, and 169. Sum DDTs (sum of concentrations oi DDT and related compounds), hexachlorobenzene (HCB), oxychlordane, transnonachlor, and sum hexachlorocyclohexanes (HCHs) (sum of concentrations of alpha-HCH, beta-HCH, and gamma-HCH) were also determined. The mean levels of sum DDTs, HCB, oxychlordane, transnonachlor, and sum HCHs were 338, 41, 9, 19, and 36 ng/g, respectively, in human milk fat p,p'-DDE and beta-HCH accounted for 81 and 93% of sum DDTs and sum HCHs, respectively. The mean level of sum PCBs (sum of mean concentrations of 20 individual congeners) was 372 ng/g milk fat. A very good correlation was found between sum PCBs and PCB-153 (r = .97). Sum PCBs determined on a capillary column was found to account for 62-79% of total PCBs calculated by using the packed column method used in previous human milk surveys in Norway. Comparison with previous results revealed that the mean sum PCB, HCB and sum DDT levels were decreased by 70, 65, and 75%, respectively during the past 9 yr. The contribution of individual PCDD/PCDF (earlier Norwegian study) and non- and mono-ortho-substituted PCB congeners to the total calculated toxic equivalent values was assessed, and the PCBs were found to constitute a major part of the TCDD equivalents in human milk, with PCB-126 as the main contributor.