Self-face recognition in children with autism spectrum disorders: A near-infrared spectroscopy study
Self-face recognition in children with autism spectrum disorders: A near-infrared spectroscopy study
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DOI：
10.1016/j.braindev.2010.11.007
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发表时间：
2011-06-01
影响因子：
1.7
通讯作者：
Hosokawa, Toru
中科院分区：
文献类型：
--
作者：
Kita, Yosuke;Gunji, Atsuko;Hosokawa, Toru
据推测，自闭症谱系障碍（ASD）的儿童有特异性的自我面孔识别，这是已知的社会发展的基本认知能力。在本研究中，我们研究了神经基板和潜在的影响因素，为ASD患者使用近红外光谱（NIRS）自我面孔识别。受试者为11名健康成年男性，13名正常发育的男孩和10名ASD男孩。在自我面孔识别过程中，他们的额区血流动力学活动和他们的扫描策略（眼动）进行了检查。其他因素如ASD严重程度和自我意识也分别由父母和患者进行评估。与左额下回对应的区域氧合血红蛋白水平高于右额下回对应的区域。在两组儿童中，这些活动反映了ASD的严重程度，因此更严重的ASD特征与较低的活动水平相对应。此外，更高水平的公众自我意识加强了活动，这是不受扫描策略。这些发现表明，负责自我面部识别的右额下回区域的功能障碍是ASD特征的关键神经基质之一，这可能被用于评估心理方面，如公众自我意识。(C)2010年日本儿童神经病学学会。Elsevier B.V.出版，保留所有权利。
It is assumed that children with autism spectrum disorders (ASD) have specificities for self-face recognition, which is known to be a basic cognitive ability for social development. In the present study, we investigated neurological substrates and potentially influential factors for self-face recognition of ASD patients using near-infrared spectroscopy (NIRS). The subjects were 11 healthy adult men, 13 normally developing boys, and 10 boys with ASD. Their hemodynamic activities in the frontal area and their scanning strategies (eye-movement) were examined during self-face recognition. Other factors such as ASD severities and self-consciousness were also evaluated by parents and patients, respectively. Oxygenated hemoglobin levels were higher in the regions corresponding to the right inferior frontal gyrus than in those corresponding to the left inferior frontal gyrus. In two groups of children these activities reflected ASD severities, such that the more serious ASD characteristics corresponded with lower activity levels. Moreover, higher levels of public self-consciousness intensified the activities, which were not influenced by the scanning strategies. These findings suggest that dysfunction in the right inferior frontal gyrus areas responsible for self-face recognition is one of the crucial neural substrates underlying ASD characteristics, which could potentially be used to evaluate psychological aspects such as public self-consciousness. (C) 2010 The Japanese Society of Child Neurology. Published by Elsevier B.V. All rights reserved.