Serum prolactin levels are positively associated with mammographic density in postmenopausal women
Serum prolactin levels are positively associated with mammographic density in postmenopausal women
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DOI：
10.1007/s10549-006-9454-y
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发表时间：
2007-11-01
影响因子：
3.8
通讯作者：
Karlamangla, Arun
中科院分区：
文献类型：
--
作者：
Greendale, Gail A.;Huang, Mei-Hua;Karlamangla, Arun
催乳素是一种多肽激素，可以促进正常乳腺的增殖和分化，但它也与乳腺肿瘤的发生和生长有关。乳房x线摄影密度是一个强有力的、独立的乳腺癌预测因子，因此，是乳腺癌风险的潜在替代指标。方法为了验证血清催乳素与乳房x线摄影密度正相关的假设，我们对绝经后雌激素/黄体酮干预（PEPI）乳房x线摄影密度研究的基线数据进行了横断面分析。基于先前的工作，我们进一步假设这种关联仅在最近未使用绝经后激素治疗（HT）的妇女中才会明显。结果在调整了年龄、体重指数、种族、吸烟、饮酒、胎次和体力活动等因素的线性回归模型中，在400名近期未使用HT的女性中，催乳素与乳房x线摄影密度呈正相关且具有统计学意义（β对数基底2催乳素为0.0369 [95% CI: 0.0094-0.0645]）。因此，血清催乳素每增加一倍，乳腺x线摄影密度绝对增加3.69%。对血清雌二醇、黄体酮、性激素结合球蛋白水平和首次怀孕年龄的额外调整不影响这一结果。在169名最近使用HT的参与者中，催乳素和乳房x线摄影密度之间没有关联。结论高催乳素与高乳腺x线密度的对应关系与催乳素的有丝分裂特性以及催乳素与乳腺肿瘤促进的关系是一致的。这些结果支持了催乳素作为降低乳腺癌风险的靶点值得研究的观点。
Background Prolactin is a polypeptide hormone that promotes normal breast proliferation and differentiation, but it is also implicated in the development and growth of mammary tumors. Mammographic density is a strong, independent predictor of breast cancer and, therefore, a potential surrogate indicator of breast cancer risk.Methods To test the hypothesis that serum prolactin is positively related to mammographic density, we conducted a cross-sectional analysis of baseline data from the Postmenopausal Estrogen/Progestin Interventions (PEPI) Mammographic Density Study. Based on prior work, we further hypothesized that this association would be apparent only in women who had not recently used postmenopausal hormone therapy (HT).Results In linear regression models adjusted for age, body mass index, race, smoking, alcohol use, parity and physical activity, among the 400 women who were not recent users of HT, prolactin was positively and statistically significantly associated with mammographic density (Beta log base 2 prolactin 0.0369 [95% CI: 0.0094-0.0645]. Thus, for each doubling of serum prolactin, there was an absolute increase in mammographic density of 3.69%. Additional adjustment for serum levels of estradiol, progesterone, sex hormone binding globulin and age at first pregnancy did not affect this result. There was no association between prolactin and mammographic density among the 169 participants who had recently used HT.Conclusion The correspondence between higher prolactin and higher mammographic density is consistent with prolactin's mitogenic properties and the associations between prolactin and breast tumor promotion. These results support the thesis that prolactin deserves investigation as a target for breast cancer risk reduction.