Polycyclic Aromatic Hydrocarbon, Haematological and Oxidative Stress Levels in Commercial Photocopier Operators In Lagos, Nigeria.
Polycyclic Aromatic Hydrocarbon, Haematological and Oxidative Stress Levels in Commercial Photocopier Operators In Lagos, Nigeria.
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DOI：
10.4314/gmj.v49i1.7
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发表时间：
2015-03-01
影响因子：
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通讯作者：
Adeyemi, O O
中科院分区：
文献类型：
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作者：
Awodele, O;Akindele, A J;Adeyemi, O O
背景：已知人类暴露于环境中的有害物质在某些疾病的发病机制中起重要作用。在尼日利亚，影印机已经成为一种廉价的自雇来源。由于显而易见的原因，最高级别的赞助是在教育机构的校园里遇到的。但是，操作机器的人员在没有防护装置的情况下总是暴露在与工作有关的潜在危险中。目的：研究复印机操作人员血液中氧化应激、多环芳烃（PAH）和血液学指标的水平。方法：实验程序包括50名同意的受试者，根据一些标准选择。采用标准方法测定血液学参数、氧化应激和多环芳烃水平。结果：两组血液学指标差异无统计学意义（p≥0.05）。然而，与对照组相比，复印机操作员的超氧化物歧化酶（SOD）水平的显著下降与工作时间（年）有关（bbb50年p≤0.0001；4-5年p≤0.001）。与对照组相比，还原型谷胱甘肽（GSH）的水平在工作的所有时间内都显著降低。结论：本研究结果显示，复印机操作员的氧化应激水平升高，但血液参数没有显著变化。复印机操作对健康的影响要求对复印机操作人员进行快速的健康教育和干预，以监测和指导复印机操作人员。这将有助于防止或管理持续暴露于复印机的危害。
BACKGROUND: Human exposure to hazardous substances in the environment has been known to play an important role in the pathogenesis of some diseases. Photocopying machines have become a cheap source of self-employment in Nigeria. For obvious reasons the highest level of patronage is encountered in the campuses of educational institutions. However, the persons who operate the machines are always exposed to possible hazards associated with the job without protective devices.OBJECTIVE: This study investigated the levels of oxidative stress, polycyclic aromatic hydrocarbon (PAH) and haematological parameters in blood samples of photocopier operators.METHODS: The experimental procedure involved 50 consented subjects selected based on some criteria. The haematological parameters, oxidative stress and PAH levels were determined using standard methods.RESULTS: The results showed no significant difference (p ≥ 0.05) in the haematological parameters between the test subjects and the controls. However, there were duration on the job (yrs) dependent significant decrease in the level of superoxide dismutase (SOD) of the photocopier operators compared with the controls (> 5 years p≤ 0.0001; 4-5 years p≤0.001). The level of reduced glutathione (GSH) was significantly decreased across all lengths of duration on the job compared with the controls.CONCLUSION: The findings in this study revealed increased level of oxidative stress in photocopier operators with no significant change in haematological parameters. The health implication of operating photocopiers call for quick health education and intervention tailored to monitoring and guiding the photocopier operators. This will help to prevent or manage continuous exposure to the hazards of photocopying machines.