Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder
Neural circuitry engaged during unsuccessful motor inhibition in pediatric bipolar disorder
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DOI：
10.1176/appi.ajp.164.1.52
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发表时间：
2007-01-01
影响因子：
17.7
通讯作者：
Pine, Daniel S.
中科院分区：
文献类型：
--
作者：
Leibenluft, Ellen;Rich, Brendan A.;Pine, Daniel S.
目的：双相情感障碍儿童的运动抑制缺陷可能与冲动和易怒有关。对儿童双相情感障碍运动抑制失败期间神经回路的研究可能会增加我们对疾病病理生理学的理解。作者检验了双相情感障碍儿童和对照受试者在不成功的运动抑制期间腹侧前额叶皮层、纹状体和前扣带回激活不同的假设。他们还比较了激活与未用药的儿童与双相情感障碍和儿童与双相情感障碍和注意缺陷多动障碍（ADHD）与那些与双相情感障碍没有ADHD.Method：作者进行了一项事件相关的功能磁共振成像研究比较神经激活儿童与双相情感障碍和健康的对照组，而他们进行了运动抑制任务。研究组包括26名儿童双相情感障碍（13未服药，15与ADHD）和17个年龄，性别，和iQ.Results匹配的比较科目：在失败的抑制试验，比较科目表现出更大的双边纹状体和右腹前额叶皮层激活比患者。这些赤字是存在于未服药的患者，但在调解他们的作用ADHD是uncleared.Conclusions：在比较科目，儿童双相情感障碍可能有缺陷的能力，从事纹状体结构和右腹前额叶皮层在不成功的抑制。进一步的研究应该确定ADHD对这些缺陷的贡献，以及这些缺陷在双相情感障碍的情绪和行为失调特征中可能发挥的作用。
Objective: Deficits in motor inhibition may contribute to impulsivity and irritability in children with bipolar disorder. Studies of the neural circuitry engaged during failed motor inhibition in pediatric bipolar disorder may increase our understanding of the pathophysiology of the illness. The authors tested the hypothesis that children with bipolar disorder and comparison subjects would differ in ventral prefrontal cortex, striatal, and anterior cingulate activation during unsuccessful motor inhibition. They also compared activation in medicated versus unmedicated children with bipolar disorder and in children with bipolar disorder and attention deficit hyperactivity disorder ( ADHD) versus those with bipolar disorder without ADHD.Method: The authors conducted an event-related functional magnetic resonance imaging study comparing neural activation in children with bipolar disorder and healthy comparison subjects while they performed a motor inhibition task. The study group included 26 children with bipolar disorder ( 13 unmedicated and 15 with ADHD) and 17 comparison subjects matched by age, gender, and IQ.Results: On failed inhibitory trials, comparison subjects showed greater bilateral striatal and right ventral prefrontal cortex activation than did patients. These deficits were present in unmedicated patients, but the role of ADHD in mediating them was unclear.Conclusions: In relation to comparison subjects, children with bipolar disorder may have deficits in their ability to engage striatal structures and the right ventral prefrontal cortex during unsuccessful inhibition. Further research should ascertain the contribution of ADHD to these deficits and the role that such deficits may play in the emotional and behavioral dysregulation characteristic of bipolar disorder.