First-trimester maternal placental protein 13 levels in pregnancies resulting in adverse outcomes
First-trimester maternal placental protein 13 levels in pregnancies resulting in adverse outcomes
复制标题
DOI：
10.1002/pd.1921
复制
发表时间：
2008-02-01
影响因子：
3
通讯作者：
Meiri, Hamutal
中科院分区：
文献类型：
--
作者：
Cowans, Nicholas J.;Spencer, Kevin;Meiri, Hamutal
在之前的一项研究中，妊娠早期母亲血清胎盘蛋白13 （PP13）水平降低与不良妊娠结局相关。本研究的目的是比较对于妊娠前三个月的PP13水平控制怀孕和怀孕导致的一个或多个以下不良结果:宫内生长受限(IUGR),小和非常小(3日,5日,第十百分位数)妊娠年龄(SGA)、低(< 1.5和< 2.5公斤)出生体重(激光焊),巨大胎儿(>第90百分位数),大出生体重(> 4.5公斤),早产(35-36周)和早期(< 34周)交付公司(PTD),宫内胎儿死亡(IUFD)。方法对1940年单胎妊娠11 ~ 14周的产妇血清中PP13的含量进行测定，并根据胎龄、体重、吸烟状况和民族血统进行校正。比较了364个对照组和1576个不良结果类别的PP13水平。PP13水平以浓度和中位数倍数（mom）表达。结果SGA、PTD和低出生体重孕妇的PP - 13与对照组比较，差异无统计学意义。尽管本研究的病例数较少，但在巨体妊娠（第90百分位）中，PP13水平显著高于对照组（p = 0.0263）。结论PP13水平的降低与IUGR、PTD、低出生体重、IUFD的不良妊娠结局无显著相关。需要进一步的研究来评估PP13的测量是否在妊娠早期评估中有任何价值。版权所有(c) 2008约翰威利父子有限公司
Background In a previous study, reduced levels of maternal serum placental protein 13 (PP13) in the first trimester have been correlated with adverse pregnancy outcomes. The objective of this study was to compare first-trimester PP13 levels in control pregnancies with pregnancies resulting in one or more of the following adverse outcomes: intrauterine growth restriction (IUGR), small and very small (3rd, 5th, 10th centile) for gestational age (SGA), low (< 1.5 and < 2.5 kg) birth weight (LBW), macrosomia (the > 90th centile), large birth weight (> 4.5 kg), preterm (35-36 weeks) and very early (< 34 weeks) delivery (PTD), and intrauterine fetal demise (IUFD).Methods Maternal serum samples from 1940, 11 to 14 weeks singleton pregnancies, were assayed for PP13 and the concentrations were corrected for gestational age, maternal weight, smoking status, and ethnic origin. A comparison of the levels of PP13 in 364 controls and 1576 adverse outcome categories was made. PP13 levels were expressed in terms of both concentration and multiple of medians (MoMs).Results Comparison of PP 13 MoMs from SGA, PTD, and low birth weight samples with control pregnancy samples showed no statistically significant difference. In macrosomic pregnancies (> 90th centile), levels of PP13 were significantly higher than controls (p = 0.0263) although the number of cases in this study was small.Conclusion Decreased levels of PP13 were not significantly correlated with the studied adverse pregnancy outcomes of IUGR, PTD low birth weight, and IUFD. Further studies are required to evaluate if measurement of PP13 has any value in the early assessment of pregnancies. Copyright (c) 2008 John Wiley & Sons, Ltd.