Leptin levels in various manifestations of pulmonary tuberculosis.
Leptin levels in various manifestations of pulmonary tuberculosis.
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DOI：
10.1155/2007/64859
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发表时间：
2007
影响因子：
4.6
通讯作者：
Ozesmi M
中科院分区：
文献类型：
--
作者：
Buyukoglan H;Gulmez I;Kelestimur F;Kart L;Oymak FS;Demir R;Ozesmi M
背景。促炎细胞因子是代谢变化的主要候选者，最终导致结核病相关的体重减轻。微生物产物和细胞因子（例如 TNF 和 IL-1）可剂量依赖性地增加脂肪组织中的瘦素表达。瘦素在细胞免疫中发挥着重要作用。目标。在这项研究中，我们调查了活动性肺结核（TB）患者抗结核治疗前后的血清瘦素和TNF-α水平。方法。 25 名活动性肺结核患者和 18 名健康对照者参与了这项研究。治疗前和治疗后6个月测量瘦素和TNF-α水平，并与对照组进行比较。还评估了治疗前后的体重指数（BMI）和胸部X光检查。结果。治疗前后瘦素水平分别为1.66±1.68 ng/mL和3.26±3.81 ng/mL。结核病患者的瘦素水平显着高于健康患者 (P < .05)。治疗前BMI为19.36±2.55 kg/m2，治疗后BMI为22.87±3.13 kg/m2。治疗前TNF-α水平为23.19±12.78 pg/mL，治疗后为15.95±6.58 pg/mL。瘦素和 TNF-α 水平之间没有相关性。胸片显示有后遗症病变的患者瘦素水平较低。结论。结核病患者的瘦素水平受到抑制，低瘦素水平可能会增加感染的易感性以及后遗症病变的恢复。
Background. Proinflammatory cytokines are prime candidates as causative agents of the metabolic changes that eventually result in tuberculosis-associated weight loss. Microbial products and cytokines such as TNF and IL-1 increase leptin expression dose dependently in adipose tissue. Leptin plays an important role in cellular immunity. Objectives. In this study, we investigated serum leptin and TNF-α levels before and after antituberculosis therapy in patients with active pulmonary tuberculosis (TB). Methods. Twenty five in patients with active pulmonary TB and 18 healthy controls participated in the study. Leptin and TNF-α levels were measured before treatment and six months after the treatment and they were compared with the control group. Body mass index (BMI) and chest X-rays before and after the treatment were also evaluated. Results. The leptin levels before and after the treatment were 1.66±1.68 ng/mL and 3.26±3.81 ng/mL, respectively. The leptin levels of tuberculous patients were significant than in healthy patients (P < .05). The BMI was 19.36 ± 2.55 kg/m2 before the treatment and 22.87 ± 3.13 kg/m2 after the treatment. The TNF-α level was 23.19±12.78 pg/mL before the treatment and 15.95±6.58 pg/mL after the treatment. There was no correlation between leptin and TNF-α levels. Leptin levels were low in patients who had sequela lesion on chest radiographs. Conclusion. Leptin levels are suppressed in tuberculous patients and low leptin levels may contribute to increased susceptibility to infection and recovery with sequela lesions.