High resolution MRI of the deep gray nuclei at 8 tesla
High resolution MRI of the deep gray nuclei at 8 tesla
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DOI：
10.1097/00004728-199911000-00009
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发表时间：
1999-11-01
影响因子：
1.3
通讯作者：
Robitaille, PML
中科院分区：
文献类型：
--
作者：
Bourekas, EC;Christofoidis, GA;Robitaille, PML
目的：高分辨率MR图像从一个正常的人类志愿者在8 T被用来描述的外观，含铁的深灰色nuclears.Method：高分辨率（1,024 × 1,024矩阵）近轴向梯度回波图像的深灰色的核被收购的人类志愿者通过使用8 T扫描仪。使用正交工作的横向电磁谐振器获取图像。使用以下参数：TR = 750 ms，TE = 17 ms，翻转角= 45度，接收器带宽= 50 kHz，切片厚度= 2 mm，FOV = 20 cm。通过将8 T图像与在较低场强下观察到的图像、已发表的图表和组织学切片进行比较，对8 T图像进行了审查，并将其与深核的已知解剖结构相关联。此外，核团的外观与已知的成像特点，脑铁在低fields.Results：尾状核，苍白球，壳核，丘脑，黑质，红核被清楚地确定。最高水平的铁，苍白球，黑质，和红核的结构，表现出显着降低的信号，提供了一个地图的铁分布在人类brain.Conclusion：初步成像在8 T演示的能力，以获得超高分辨率图像的深核，信号特征被认为是代表脑铁的分布。这可能被证明是重要的几个神经退行性疾病的早期诊断。
Purpose: High resolution MR images obtained from a normal human volunteer at 8 T are utilized to describe the appearance of iron-containing deep gray nuclei at this field strength.Method: High resolution (1,024 x 1,024 matrix) near-axial gradient echo images of the deep gray nuclei were acquired on a human volunteer by using an 8 T scanner. The images were acquired using a transverse electromagnetic resonator operating in quadrature. The following parameters were utilized: TR = 750 ms, TE = 17 ms, flip angle = 45 degrees, receiver bandwidth = 50 kHz, slice thickness = 2 mm, FOV = 20 cm. The 8 T images were reviewed and correlated to the known anatomy of the deep nuclei by comparing them with images observed at lower field strength, published diagrams, and histologic sections. In addition, the appearance of the nuclei was related to the known imaging characteristics of brain iron at lower fields.Results: The caudate, globus pallidus, putamen, thalami, substantia nigra, and red nuclei were clearly identified. The structures with the highest levels of iron, the globus pallidus, substantia nigra, and red nuclei, demonstrated significantly decreased signal, providing a map of iron distribution in the human brain.Conclusion: Preliminary imaging at 8 T demonstrates the ability to acquire ultra high resolution images of the deep nuclei, with signal characteristics believed to represent the distribution of brain iron. This may prove to be important in the early diagnosis of several neurodegenerative disorders.