Two circadian rhythms in the human electroencephalogram during wakefulness
Two circadian rhythms in the human electroencephalogram during wakefulness
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DOI：
10.1152/ajpregu.1999.277.6.r1771
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发表时间：
1999-12-01
影响因子：
2.8
通讯作者：
Wehr, TA
中科院分区：
文献类型：
--
作者：
Aeschbach, D;Matthews, JR;Wehr, TA
本文观察了19名正常人在接近40h的持续清醒状态下，昼夜节律起搏器和清醒时间对脑电的影响。得出了频谱功率密度的两个昼夜节律。第一次节律集中在theta频段(4.25-8.0 Hz)，最小节律出现在褪黑素分泌开始后1h。第二节律集中在高频阿尔法频段(10.25-13.0赫兹)，最低值接近体温最低值。后者的节律与主观警觉性、血浆褪黑素和体温的节律有密切的时间联系。此外，觉醒时间的增加与0.25至9.0赫兹和13.25至20.0赫兹范围内的功率密度增加有关。结论：清醒脑电经历的变化可归因于昼夜节律和动态平衡(即，依赖于睡眠蛋糕)过程。脑电活动在theta频段和高频α频段的明显昼夜变化可能代表了觉醒过程中昼夜节律的不同方面的电生理关联。
The influence of the circadian pacemaker and of the duration of time awake on the electroencephalogram (EEG) was investigated in 19 humans during similar to 40 h of sustained wakefulness. Two circadian rhythms in spectral power density were educed. The first rhythm was centered in the theta band (4.25-8.0 Hz) and exhibited a minimum similar to 1 h after the onset of melatonin secretion. The second rhythm was centered in the high-frequency alpha band (10.25-13.0 Hz) and exhibited a minimum close to the body temperature minimum. The latter rhythm showed a close temporal association with the rhythms in subjective alertness, plasma melatonin, and body temperature. In addition, increasing time awake was associated with an increase of power density in the 0.25- to 9.0-Hz and 13.25- to 20.0-Hz ranges. It is concluded that the waking EEG undergoes changes that can be attributed to circadian and homeostatic (i.e., sleep-cake dependent) processes. The distinct circadian variations of EEG activity in the theta band and in the high-frequency alpha band may represent electrophysiological correlates of different aspects of the circadian rhythm in arousal.