Higher serum concentrations of betaine rather than choline is associated with better profiles of DXA-derived body fat and fat distribution in Chinese adults
Higher serum concentrations of betaine rather than choline is associated with better profiles of DXA-derived body fat and fat distribution in Chinese adults
复制标题
中国成年人血清中甜菜碱浓度高于胆碱，与 DXA 衍生的身体脂肪和脂肪分布状况更好相关
DOI：
10.1038/ijo.2014.158
复制
发表时间：
2015-03-01
影响因子：
4.9
通讯作者：
Zhu, H-l
中科院分区：
文献类型：
--
作者：
Chen, Y-m;Liu, Y.;Zhu, H-l
目的：动物研究表明，甜菜碱，而不是胆碱，可能会改善身体成分，但在人类身上几乎没有证据可用。方法：以社区为基础，在广州市区调查了1996名40~75岁成年人(男1380人，男1380人)，年龄在40~75岁。在2008年7月至2010年6月期间，进行了一般信息和人体测量，并用高效液相色谱-串联质谱仪评估了血清胆碱和甜菜碱水平。3.2年后，对1996名参与者中的1623人进行了全身(TB)、躯干、四肢、机器人(A)和雌核(G)区域的脂肪质量(Fm和%Fm)测量。结果：单因素分析显示，血清甜菜碱水平的升高与肥胖指数的降低显著相关(均P<0.05)，但雌核部位的%FM除外。在调整了潜在的协变量后，观察到了类似的相关性。血清甜菜碱水平第4和第1四分位数之间的平均百分比差异分别为−4.9%(体重)、−4.7%(体重指数)、−2.5%(腰围)、−7.9%(TB FM)和−3.4%(TB%FM)。Fm和%Fm在躯干(−10.0和−4.5%)或安卓区(−10.7和−4.7%)比四肢(−0.8和−2.3%)或女性区(−0.6和−1.4%)更明显。这种有利的联想在男性中比在女性中更强。除了体重和体重指数外，血清胆碱与肥胖指数之间没有显著的相关性。结论：在该人群中，由于躯干部位较低的FM，血液中更多的甜菜碱，而不是胆碱，与更好的身体成分和脂肪分布呈剂量依赖关系。
Objective:Animal studies have suggested that betaine, but not choline, may improve body composition, but little evidence is available in humans. We examined the association of serum concentrations of choline and betaine with body composition and fat distribution in adults.Methods:This community-based study recruited 1996 adults (women/men: 1380/616) aged 40–75 years in urban Guangzhou, China. General information and anthropometric measurements were taken, and serum choline and betaine levels were assessed by high-performance liquid chromatography–tandem mass spectrometry between July 2008 and June 2010. After 3.2 years, 1623 of the 1996 participants were measured for fat mass (FM and% FM) over the total body (TB), trunk, limbs, android (A) and gynoid (G) regions. The% FM ratios of the A/G regions and the trunk and limbs were determined by dual energy X-ray absorptiometry.Results:Univariate analyses showed that higher serum betaine levels were significantly associated with lower values of adiposity indices (all P-trends< 0.05), except in the case of the% FM at the gynoid area. After adjusting for potential covariates, similar associations were observed. The mean percentage differences between quartiles 4 and 1 of the serum betaine levels were− 4.9%(weight),− 4.7%(body mass index, BMI),− 2.5%(waist circumference),− 7.9%(TB FM) and− 3.4%(TB% FM). The mean differences in the FM and% FM were much more pronounced at the trunk (− 10.0 and− 4.5%) or android areas (− 10.7 and− 4.7%) than those at the limbs (− 0.8 and− 2.3%) or gynoid areas (− 0.6 and− 1.4%). Such favorable associations were stronger in men than in women. No significant associations between serum choline and the adiposity indices were observed, except in the cases of body weight and BMI.Conclusions:Greater circulating betaine, but not choline, was dose-dependently associated with better body composition and fat distribution due to a lower FM in the trunk regions in this population.