Sex differences and hormonal control of histamine methyltransferase activity.
Sex differences and hormonal control of histamine methyltransferase activity.
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组胺甲基转移酶活性的性别差异和激素控制。
DOI：
10.1016/0304-4165(65)90051-6
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发表时间：
1965
期刊：
影响因子：
--
通讯作者：
J. Axelrod
中科院分区：
文献类型：
--
作者：
S. Snyder;J. Axelrod
雄性大鼠肾脏的组胺甲基转移酶（S-腺苷甲硫氨酸：组胺N-甲基转移酶，EC 2.1.1.8）活性是雌性大鼠肾脏的两倍。分别对完整的雄性和雌性动物给予雌二醇和睾酮不会影响酶活性的性别差异。阉割减少男性活动;阉割的效果可以通过单剂量的睾酮逆转。卵巢切除术不影响女性肾脏组胺甲基转移酶活性。然而，单次注射睾酮可提高切除卵巢的雌性动物的酶活性。与大鼠相比，雌性小鼠的肾脏活性是雄性小鼠的两倍。大鼠肾脏组胺甲基转移酶活性的性别差异可以解释大鼠尿组胺排泄的性别差异。
Kidneys from male rats have twice as much histamine methyltransferase (S-adenosylmethionine:histamineN-methyltransferase, EC 2.1.1.8) activity as kidneys from female rats. Estradiol and testosterone administration to intact males and females respectively does not affect the sex difference in enzyme activity. Castration reduces male activity; the effect of castration can be reversed by a single dose of testosterone. Oophorectomy does not affect female kidney histamine methyltransferase activity. A single injection of testosterone, however, elevates enzyme activity of oophorectomized females. In contrast to rats, the kidneys of female mice contain twice the activity of male kidneys. The sex difference in histamine methyltransferase activity of rat kidneys can explain the sex differences in urinary histamine excretion in rats.