Higher muscle protein synthesis in women than men across the lifespan, and failure of androgen administration to amend age-related decrements
Higher muscle protein synthesis in women than men across the lifespan, and failure of androgen administration to amend age-related decrements
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DOI：
10.1096/fj.08-117200
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发表时间：
2009-02-01
期刊：
影响因子：
4.8
通讯作者：
Nair, K. Sreekumaran
中科院分区：
文献类型：
--
作者：
Henderson, Gregory C.;Dhatariya, Ketan;Nair, K. Sreekumaran
我们研究了年龄和性别的影响，并确定了老年个体(=60岁)的雄激素替代是否可以增加蛋白质的合成。30名年轻男性和32名年轻女性(18-31岁)进行了一次研究，87名老年男性在治疗前和治疗后1年分别服用5 mg/d睾酮(T)、75 mg/d脱氢表雄酮(DHEA)或安慰剂(P)，57名老年女性在治疗前和治疗1年后分别服用50 mg/d DHEA或P。[n-15]苯丙氨酸和[H-2(4)]酪氨酸示踪剂注入，测量血浆和股外侧肌。老年人单位脱脂体重的全身蛋白质合成量和肌肉蛋白质合成率(FSR)均低于青年组(P
We investigated age and sex effects and determined whether androgen replacement in elderly individuals (>= 60 yr) could augment protein synthesis. Thirty young men and 32 young women (18-31 yr) were studied once, whereas 87 elderly men were studied before and after 1 yr of treatment with 5 mg/day testosterone (T), 75 mg/day dehydroepiandrosterone (DHEA), or placebo (P); and 57 elderly women were studied before and after 1 yr of treatment with 50 mg/day DHEA or P. [N-15] Phenylalanine and [H-2(4)] tyrosine tracers were infused, with measurements in plasma and vastus lateralis muscle. Whole-body protein synthesis per fat-free mass and muscle protein fractional synthesis rate (FSR) were lower in elderly than in young individuals (P