Inhibition of Na+/H+ exchanger 1 by cariporide alleviates burn-induced multiple organ injury.
Inhibition of Na+/H+ exchanger 1 by cariporide alleviates burn-induced multiple organ injury.
复制标题
卡立泊利对 Na /H 交换器 1 的抑制可减轻烧伤引起的多器官损伤。
DOI：
10.1016/j.jss.2013.06.049
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发表时间：
2013-12
影响因子：
2.2
通讯作者：
杨薛康
中科院分区：
文献类型：
--
作者：
杨薛康
背景严重烧伤可引起以促炎细胞因子表达上调为特征的炎症反应，导致多器官损伤。Na+/H+交换器1（NHE 1）在多种炎症过程中起重要作用。本研究旨在探讨NHE 1在烧伤诱导的炎症和多器官injuries.Materials和MethodsRats的作用进行了30%的全身表面积全层烧伤。Cariporide被用来评估NHE 1在烧伤引起的多器官损伤的生化参数，组织学变化，和炎症细胞因子production.ResultsWe发现，烧伤后NHE 1的表达显着增加。Cariporide抑制NHE 1可减轻烧伤引起的水肿和心、肺、肾和小肠的组织损伤。Cariporide也抑制血浆肿瘤坏死因子α，白细胞介素6，和髓过氧化物酶activity.ConclusionsThese结果表明，NHE 1抑制防止烧伤引起的多器官损伤。由NHE 1抑制提供的有益效果至少部分地通过减弱全身炎症反应来介导。
BackgroundSevere burns initiate an inflammatory response characterized by the upregulation of proinflammatory cytokine, which contributes to multiple organ injury. Na+/H+exchanger 1 (NHE1) plays a significant role in several inflammatory processes. This study was designed to investigate the role of NHE1 in burn-induced inflammation and multiple organ injury.Materials and methodsRats were subjected to a 30% total body surface area full-thickness burn. Cariporide was used to assess the function of NHE1 in burn-induced multiple organ injury by biochemical parameters, histologic changes, and inflammatory cytokine production.ResultsWe found that NHE1 expression was significantly increased after burn injury. Inhibition of NHE1 by cariporide attenuated burn-induced edema and tissue injury in heart, lung, kidney, and small intestine. Cariporide also inhibited plasma levels of tumor necrosis factor α, interleukin 6, and myeloperoxidase activity.ConclusionsThese results indicate that NHE1 inhibition prevents burn-induced multiple organ injury. The salutary effects afforded by NHE1 inhibition, at least in part, are mediated by attenuating systemic inflammatory response.
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