Different manifestations of Toxoplasma gondii infection in F344 and LEW rats
Different manifestations of Toxoplasma gondii infection in F344 and LEW rats
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DOI：
10.1007/s004300050085
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发表时间：
1999-03-01
影响因子：
5.4
通讯作者：
Sutton, P
中科院分区：
文献类型：
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作者：
Kempf, MC;Cesbron-Delauw, MF;Sutton, P
有证据表明，不仅免疫状态，某些宿主的遗传倾向也会影响弓形虫感染的临床结果。到目前为止，我们关于控制弓形虫感染的遗传和免疫学机制的大部分知识都是通过研究小鼠模型获得的，而小鼠模型在感染的临床结果方面与人类有很大不同。与人类相比，老鼠表现出相当相似的感染过程，迄今为止尚未研究遗传差异对感染过程的影响。在这项研究中，我们发现，与小鼠一样，不同品系的大鼠在慢性感染引起的脑囊肿数量上表现出显着的差异。与易受影响的 F344 大鼠相比，LEW 大鼠似乎对囊肿形成具有高度抵抗力。此外，F344 大鼠在感染急性期表达大量 γ δ T 细胞，而 LEW 大鼠表达升高但相对较低数量的 γ δ T 细胞。两种菌株的 RT1（大鼠 MHC）单倍型在 RT1A 和 RT1B/D 区域中是相同的，这些区域编码常规肽抗原的限制元件。因此，大鼠品系特异性差异可能有助于定义独立于 MHC 的弓形虫耐药机制，这种机制也可能作用于人类。
There is evidence that not only the immune status, but also the genetic predisposition of certain hosts influence the clinical outcome of Toxoplasma gondii infection. By far the majority of our knowledge on genetic and immunological mechanisms involved in control of T. gondii infection has been obtained by studying mouse models, which in terms of clinical outcome of infection differ considerably from humans. Rats which show a rather similar course of infection in comparison to humans have not so far been investigated for effects of genetic differences on course of the infection. In this study we show that, like mice, different strains of rats exhibit a remarkable variation in the number of brain cysts arising from chronic infection. LEW rats seem to be highly resistant to cyst formation, in contrast to F344 rats that are susceptible. In addition, F344 rats express high numbers of gamma delta T cells during the acute phase of infection, whereas LEW rats express elevated but comparably low numbers of gamma delta T cells. The RT1 (rat MHC) haplotypes of both strains are identical in the RT1A and RT1B/D regions, which encode the restriction elements for conventional peptide antigens. Consequently, rat strain-specific differences may be useful to define MHC-independent mechanisms of resistance against T. gondii, which may also act in humans.