Bilateral recovery of striatal dopamine after unilateral adrenal grafting into the striatum of the 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'CH3-MPTP)-treated mouse.
Bilateral recovery of striatal dopamine after unilateral adrenal grafting into the striatum of the 1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine (2'CH3-MPTP)-treated mouse.
复制标题
将单侧肾上腺移植到 1-甲基-4-(2-甲基苯基)-1,2,3,6-四氢吡啶 (2CH3-MPTP) 处理的小鼠纹状体后，纹状体多巴胺的双侧恢复。
DOI：
10.1002/jnr.490250303
复制
发表时间：
1990
影响因子：
4.2
通讯作者：
Kanuicki,M
中科院分区：
文献类型：
--
作者：
Bohn,MC;Kanuicki,M
采用1‐甲基‐4‐（2′甲基苯基）‐1,2,3,6‐四氢吡啶处理的小鼠帕金森病啮齿动物模型，测定肾上腺髓质移植到纹状体后纹状体多巴胺水平是否恢复。进行了四种类型的移植：(1)成年小鼠肾上腺髓质，(2)冻融后杀死活细胞的成年肾上腺髓质，(3)出生后第7天的肾上腺髓质，(4)缺乏组织的假移植。移植后1个月，只有出生后第7天的移植物含有存活细胞。然而，所有三种类型的组织移植物都促进了移植物一侧宿主多巴胺能纤维的单侧恢复。与单侧多巴胺能纤维的恢复形成鲜明对比的是，所有组织移植小鼠的纹状体多巴胺水平都增加了。这些观察结果表明，肾上腺组织移植到纹状体中，无论其是否存活，对宿主多巴胺能系统的生化影响比以前认识到的要广泛得多。此外，这些观察结果可能支持在接受肾上腺组织纹状体移植的人类帕金森病患者中运动障碍普遍恢复的机制。
A rodent model of Parkinson's disease, the 1‐methyl‐4‐(2′methylphenyl)‐1,2,3,6‐tetrahydropyridine treated mouse, was used to determine whether striatal dopamine levels recover following grafting adrenal medulla into the striatum. Four types of grafts were performed: (1) adult mouse adrenal medulla, (2) adult adrenal medulla that had been freeze‐thawed to kill viable cells, (3) postnatal day 7 adrenal medulla, and (4) sham grafts lacking tissue. At 1 month after grafting, only postnatal day 7 grafts contained surviving cells. However, all three types of tissue grafts promoted a unilateral recovery of host dopaminergic fibers on the side of the graft. In striking contrast to the unilateral recovery of the dopaminergic fibers, striatal dopamine levels were increased bilaterally in all tissue grafted mice. These observations suggest that adrenal tissue grafted into the striatum, whether it remains viable or not, has more widespread biochemical effects on the host dopaminergic system than previously recognized. Moreover, these observations bear on mechanisms that may underlie the general recovery of motor disturbances reported in human Parkinson's disease patients who have received a striatal graft of adrenal tissue.