FOXP transcription factors in vertebrate brain development, function, and disorders.
FOXP transcription factors in vertebrate brain development, function, and disorders.
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DOI：
10.1002/wdev.375
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发表时间：
2020-09
期刊：
影响因子：
--
通讯作者：
Konopka G
中科院分区：
文献类型：
--
作者：
Co M;Anderson AG;Konopka G
FOXP转录因子是一个进化上古老的蛋白质亚家族，在脊椎动物体内协调多个器官系统的发育。它们的基因与神经发育障碍的关联引发了人们对它们在大脑中的表达模式和功能的特别兴趣。在此，FOXP1、FOXP2和FOXP4在多个区域以不同的细胞类型特异性时空模式表达，包括皮质、海马、杏仁核、基底神经节、丘脑和小脑。这些不同的表达位点和时间点使将FOXP1和FOXP2突变与其各自的发育障碍联系起来的努力变得复杂，前者影响全局神经功能，后者特别影响言语和语言。然而，使用动物模型，特别是那些脑区域和细胞类型特异性操作，大大提高了我们的理解FOXP的表达模式可能是疾病相关表型的基础。虽然关于FOXP在大脑中的表达和功能仍存在许多问题，但迄今为止的研究已经阐明了这些转录因子在脊椎动物大脑发育中的作用，并极大地告知了我们对人类发育和疾病的理解。FOXP转录因子在大脑中具有不同的表达模式，动物模型中的操作正在解开它们的时空表达与神经发育障碍病因学的联系。
FOXP transcription factors are an evolutionarily ancient protein subfamily coordinating the development of several organ systems in the vertebrate body. Association of their genes with neurodevelopmental disorders has sparked particular interest in their expression patterns and functions in the brain. Here, FOXP1, FOXP2, and FOXP4 are expressed in distinct cell type-specific spatiotemporal patterns in multiple regions, including the cortex, hippocampus, amygdala, basal ganglia, thalamus, and cerebellum. These varied sites and timepoints of expression have complicated efforts to link FOXP1 and FOXP2 mutations to their respective developmental disorders, the former affecting global neural functions and the latter specifically affecting speech and language. However, the use of animal models, particularly those with brain region- and cell type-specific manipulations, has greatly advanced our understanding of how FOXP expression patterns could underlie disorder-related phenotypes. While many questions remain regarding FOXP expression and function in the brain, studies to date have illuminated the roles of these transcription factors in vertebrate brain development and have greatly informed our understanding of human development and disorders. FOXP transcription factors have distinct expression patterns in the brain, and manipulations in animal models are disentangling how their spatiotemporal expression is linked to neurodevelopmental disorder etiology.
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FOXP2表达在Muroid啮齿动物中的保护和多样性：功能含义。
DOI：
10.1002/cne.21881
发表时间：
2009-01-01
期刊：
The Journal of comparative neurology
影响因子：
--
作者：
Campbell P;Reep RL;Stoll ML;Ophir AG;Phelps SM
通讯作者：
Phelps SM
影响因子：
25
作者：
Chen, Yi-Chuan;Kuo, Hsiao-Ying;Bornschein, Ulrich;Takahashi, Hiroshi;Chen, Shih-Yun;Lu, Kuan-Ming;Yang, Hao-Yu;Chen, Gui-May;Lin, Jing-Ruei;Lee, Yi-Hsin;Chou, Yun-Chia;Cheng, Sin-Jhong;Chien, Cheng-Ting;Enard, Wolfgang;Hevers, Wulf;Paeaebo, Svante;Graybiel, Ann M.;Liu, Fu-Chin
通讯作者：
Liu, Fu-Chin
影响因子：
5.3
作者：
Casey JP;Magalhaes T;Conroy JM;Regan R;Shah N;Anney R;Shields DC;Abrahams BS;Almeida J;Bacchelli E;Bailey AJ;Baird G;Battaglia A;Berney T;Bolshakova N;Bolton PF;Bourgeron T;Brennan S;Cali P;Correia C;Corsello C;Coutanche M;Dawson G;de Jonge M;Delorme R;Duketis E;Duque F;Estes A;Farrar P;Fernandez BA;Folstein SE;Foley S;Fombonne E;Freitag CM;Gilbert J;Gillberg C;Glessner JT;Green J;Guter SJ;Hakonarson H;Holt R;Hughes G;Hus V;Igliozzi R;Kim C;Klauck SM;Kolevzon A;Lamb JA;Leboyer M;Le Couteur A;Leventhal BL;Lord C;Lund SC;Maestrini E;Mantoulan C;Marshall CR;McConachie H;McDougle CJ;McGrath J;McMahon WM;Merikangas A;Miller J;Minopoli F;Mirza GK;Munson J;Nelson SF;Nygren G;Oliveira G;Pagnamenta AT;Papanikolaou K;Parr JR;Parrini B;Pickles A;Pinto D;Piven J;Posey DJ;Poustka A;Poustka F;Ragoussis J;Roge B;Rutter ML;Sequeira AF;Soorya L;Sousa I;Sykes N;Stoppioni V;Tancredi R;Tauber M;Thompson AP;Thomson S;Tsiantis J;Van Engeland H;Vincent JB;Volkmar F;Vorstman JA;Wallace S;Wang K;Wassink TH;White K;Wing K;Wittemeyer K;Yaspan BL;Zwaigenbaum L;Betancur C;Buxbaum JD;Cantor RM;Cook EH;Coon H;Cuccaro ML;Geschwind DH;Haines JL;Hallmayer J;Monaco AP;Nurnberger JI Jr;Pericak-Vance MA;Schellenberg GD;Scherer SW;Sutcliffe JS;Szatmari P;Vieland VJ;Wijsman EM;Green A;Gill M;Gallagher L;Vicente A;Ennis S
通讯作者：
Ennis S
影响因子：
30.8
作者：
Coe, Bradley P.;Stessman, Holly A. F.;Eichler, Evan E.
通讯作者：
Eichler, Evan E.
影响因子：
64.5
作者：
Dasen, Jeremy S.;De Camilli, Alessandro;Jessell, Thomas M.
通讯作者：
Jessell, Thomas M.