When Memory Does Not Serve You Well.
When Memory Does Not Serve You Well.
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当记忆力不济时。
DOI：
10.1161/circresaha.120.316650
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发表时间：
2020
影响因子：
20.1
通讯作者：
Mathis,KeisaW
中科院分区：
文献类型：
--
作者：
Shimoura,CarolineG;Mathis,KeisaW
免疫系统激活在高血压的进展和维持中是关键的。1获得性免疫的特殊作用已在严重联合免疫缺陷小鼠和Rag-1（重组酶激活基因-1）基因敲除小鼠中得到证实，这两种小鼠缺乏T和B细胞，并受到实验性高血压的保护。2，3进一步的研究表明，将T细胞而不是B细胞过继转移到Rag-1敲除小鼠中会消除这种保护作用并增加血压，2这表明T细胞在高血压的发病机制中发挥着重要作用。
Immune system activation is pivotal in the progression and maintenance of hypertension. 1 The specific role of adaptive immunity has been demonstrated in severe combined immunodeficiency mice and Rag-1 (recombinase activating gene-1) knockout mice, 2 strains that lack T and B cells and that are protected from experimental hypertension. 2, 3 Further studies showed that adoptive transfer of T cells but not B cells into Rag-1 knockout mice eliminates this protection and increases blood pressure, 2 suggesting an important role for T cells in the pathogenesis of the hypertension.