(129) Xe chemical shift in human blood and pulmonary blood oxygenation measurement in humans using hyperpolarized (129) Xe NMR.
(129) Xe chemical shift in human blood and pulmonary blood oxygenation measurement in humans using hyperpolarized (129) Xe NMR.
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DOI：
10.1002/mrm.26225
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发表时间：
2017-04
影响因子：
3.3
通讯作者：
Wild JM
中科院分区：
文献类型：
--
作者：
Norquay G;Leung G;Stewart NJ;Wolber J;Wild JM
评估129Xe -红细胞（RBC）化学位移对血液氧合的依赖性，并利用超极化129Xe核磁共振无创测量体内肺血氧合。在体外用不同氧合的血液样本平衡超极化129Xe，并在1.5 T和3 T时进行核磁共振，在3 T时对两名健康志愿者吸入超极化129Xe后进行屏气呼吸暂停期间的体内动态核磁共振。研究发现，在1.5 T和3 T时，红细胞中的129Xe化学位移随血液氧合呈非线性增加。在屏气呼吸暂停期间，红细胞中的129Xe化学位移表现出周期性的时间调制，在35 s的屏气呼吸中，化学位移净减少约1 ppm，相当于红细胞氧合减少7 - 10%。129Xe - RBC信号振幅显示出与129Xe - RBC化学位移相同频率的调制。使用129Xe - RBC化学位移测量体内肺血氧的可行性已被证明。129Xe - RBC信号与肺中129Xe - RBC化学位移调节之间的相关性值得进一步研究，目的是更好地量化心肺血管回路的时间血氧变化。中华医学杂志（英文版），2017。©2016作者医学磁共振由Wiley期刊公司代表国际医学磁共振学会出版。这是一篇基于知识共享署名许可协议的开放获取文章，该协议允许在任何媒体上使用、分发和复制，前提是正确引用原始作品。
To evaluate the dependency of the 129Xe‐red blood cell (RBC) chemical shift on blood oxygenation, and to use this relation for noninvasive measurement of pulmonary blood oxygenation in vivo with hyperpolarized 129Xe NMR. Hyperpolarized 129Xe was equilibrated with blood samples of varying oxygenation in vitro, and NMR was performed at 1.5 T and 3 T. Dynamic in vivo NMR during breath hold apnea was performed at 3 T on two healthy volunteers following inhalation of hyperpolarized 129Xe. The 129Xe chemical shift in RBCs was found to increase nonlinearly with blood oxygenation at 1.5 T and 3 T. During breath hold apnea, the 129Xe chemical shift in RBCs exhibited a periodic time modulation and showed a net decrease in chemical shift of ∼1 ppm over a 35 s breath hold, corresponding to a decrease of 7–10 % in RBC oxygenation. The 129Xe‐RBC signal amplitude showed a modulation with the same frequency as the 129Xe‐RBC chemical shift. The feasibility of using the 129Xe‐RBC chemical shift to measure pulmonary blood oxygenation in vivo has been demonstrated. Correlation between 129Xe‐RBC signal and 129Xe‐RBC chemical shift modulations in the lung warrants further investigation, with the aim to better quantify temporal blood oxygenation changes in the cardiopulmonary vascular circuit. Magn Reson Med 77:1399–1408, 2017. © 2016 The Authors Magnetic Resonance in Medicine published by Wiley Periodicals, Inc. on behalf of International Society for Magnetic Resonance in Medicine. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.