The Growth of Human Scalp Hair Mediated by Visible Red Light Laser and LED Sources in Males
The Growth of Human Scalp Hair Mediated by Visible Red Light Laser and LED Sources in Males
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DOI：
10.1002/lsm.22173
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发表时间：
2013-10-01
影响因子：
2.4
通讯作者：
Kazmirek, Eric R.
中科院分区：
文献类型：
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作者：
Lanzafame, Raymond J.;Blanche, Raymond R.;Kazmirek, Eric R.
背景和目的低强度激光治疗(LLLT)已被用于促进头发生长。为确定LLLT治疗男性雄激素性脱发的安全性和生理学效应，采用双盲随机对照试验。选择一个过渡区头皮部位；将头发修剪到3 mm高；对该区域进行纹身和拍照。活动组接受TOPHAT655装置，在自行车头盔状的装置中，包含21.5 mW激光(6555 Nm)和30个LED(65520 Nm)。安慰剂组的单位看起来是一样的，包含白炽灯。患者每隔一天在家治疗16周(60次治疗，67.3J/cm(2)照射/25min治疗)，16周后进行随访和照相。另一名盲人对2.85厘米(2)的遮盖照相区域进行了评估。结果41名患者完成了这项研究(22名活动患者，19名安慰剂)。没有不良事件或副作用的报道。基础发数安慰剂组为162.7+/-95.9(N=22)，活动组为142.0+/-73.00(N=22)(P=0.426)。治疗后发数分别为162.4±62.5(N=19)和228.7+/-102.8(N=22)(P=0.0161)。头发增加了39%(28.4%+/-46.2%，N=19；67.2%+/-33.4%，活跃，N=22)(P=0.001)删除一个基线数量很高和非常大减少的安慰剂组受试者，导致基线毛发数量分别为151.1+/-81.0%(N=21)和142.0+/-73.0%(N=22)(P=0.680)。治疗后头发数分别为158.2+/-61.5(N=18)和228.7+/-102.8(N=22)(P=0.011)，头发生长量增加35%(安慰剂组32.3%+/-44.2%，安慰剂组18例；活动期67.2%+/-33.4%，N=22例)(P=0.003)。激光外科医生。2013年45：487-495。(C)2013年威利期刊公司。
Background and ObjectivesLow level laser therapy (LLLT) has been used to promote hair growth. A double-blind randomized controlled trial was undertaken to define the safety and physiologic effects of LLLT on males with androgenic alopecia.MethodsForty-four males (18-48 yo, Fitzpatrick I-IV, Hamilton-Norwood IIa-V) were recruited. A transition zone scalp site was selected; hairs were trimmed to 3mm height; the area was tattooed and photographed. The active group received a TOPHAT655 unit containing 21, 5mW lasers (6555nm), and 30 LEDS (65520nm), in a bicycle-helmet like apparatus. The placebo group unit appeared identical, containing incandescent red lights. Patients treated at home every other dayx16 weeks (60 treatments, 67.3J/cm(2) irradiance/25minute treatment), with follow up and photography at 16 weeks. A masked 2.85cm(2) photographic area was evaluated by another blinded investigator. The primary endpoint was the percent increase in hair counts from baseline.ResultsForty-one patients completed the study (22 active, 19 placebo). No adverse events or side effects were reported. Baseline hair counts were 162.7 +/- 95.9 (N=22) in placebo and 142.0 +/- 73.0 (N=22) and active groups respectively (P=0.426). Post Treatment hair counts were 162.4 +/- 62.5 (N=19) and 228.7 +/- 102.8 (N=22), respectively (P=0.0161). A 39% percent hair increase was demonstrated (28.4 +/- 46.2 placebo, N=19; 67.2 +/- 33.4, active, N=22) (P=0.001) Deleting one placebo group subject with a very high baseline count and a very large decrease, resulted in baseline hair counts of 151.1 +/- 81.0 (N=21) and 142.0 +/- 73.0 (N=22), respectively (P=0.680). Post treatment hair counts were 158.2 +/- 61.5 (N=18) and 228.7 +/- 102.8 (N=22) (P=0.011), resulting in a 35% percent increase in hair growth (32.3 +/- 44.2, placebo, N=18; 67.2 +/- 33.4, active, N=22) (P=0.003).ConclusionsLLLT of the scalp at 655nm significantly improved hair counts in males with androgenetic alopecia. Lasers Surg. Med. 45:487-495, 2013. (c) 2013 Wiley Periodicals, Inc.