Fabrication of polydopamine-based layer-by-layer nanocomposites for combined pH-sensitive chemotherapy and photothermal therapy
Fabrication of polydopamine-based layer-by-layer nanocomposites for combined pH-sensitive chemotherapy and photothermal therapy
复制标题
基于聚多巴胺的逐层纳米复合材料的制备，用于 pH 敏感化疗和光热联合治疗
DOI：
10.1016/j.colsurfa.2018.10.072
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发表时间：
2019-01-20
影响因子：
5.2
通讯作者：
Jiang, Lei
中科院分区：
文献类型：
--
作者：
Ma, Hongchao;Li, Shuo;Jiang, Lei
联合治疗策略由于其提高的治疗效果和减少的副作用，在癌症治疗中引起了极大的关注。本文描述了基于PDA@(PDDA - ADA)₃ - 多柔比星（Dox）纳米复合材料的癌症化学 - 光热联合治疗。聚多巴胺（PDA）不仅作为具有强近红外吸收和高能量转换效率的光热剂，而且作为核心材料，通过层层自组装（LBL）方法交替沉积带正电的聚二烯丙基二甲基氯化铵（PDDA）和带负电的海藻酸钠二醛（ADA）来携带多层膜。盐酸多柔比星（Dox）通过席夫碱键和静电相互作用负载到PDA@(PDDA - ADA)₃纳米平台上。所制备的PDA@(PDDA - ADA)₃ - Dox纳米复合材料表现出优异的pH敏感药物释放、良好的生物相容性和高光热转换效率。这些特性使它们通过化学 - 光热联合治疗实现了出色的抗癌治疗效果。这项工作指出，基于PDA的纳米平台可以成为癌症治疗的通用支架。
The combined therapeutic strategy have aroused significant interest in cancer therapy due to its enhanced treatment efficacy and reduced side effects. This paper describes the combined chemo- and photothermal therapy of cancer based on PDA@(PDDA-ADA) 3-Dox nanocomposites. Polydopamine (PDA) serves not only as photothermal agent with strong near infrared absorbance and high energy conversion efficiency, but also as a core material to carry multilayer films formed by alternatively deposition of positively charged poly(diallyldimethylammonium chloride) (PDDA) and negatively charged alginate dialdehyde (ADA) through layer-by-layer (LBL) method. Doxorubicin hydrochloride (Dox) was loaded to the PDA@(PDDA-ADA) 3 nanoplatform via Schiff base bond and electrostatic interaction. The fabricated PDA@(PDDA-ADA)(3)-Dox nanocomposites exhibit outstanding pH-sensitive drug release, good biocompatibility and high photothermal conversion efficiency. These features make them achieve excellent anticancer therapeutic efficacy by combined chemo- and photothermal therapy. This work points that the PDA-based nanoplatform can be a universal scaffold for cancer treatment.