Artifactual effects of hypernatremia and hyponatremia on red cell analytes measured by the Bayer H*1 analyzer
Artifactual effects of hypernatremia and hyponatremia on red cell analytes measured by the Bayer H*1 analyzer
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DOI：
10.1111/j.1939-165x.1999.tb01055.x
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发表时间：
1999-01-01
影响因子：
1.2
通讯作者：
Scott, MA
中科院分区：
文献类型：
--
作者：
Boisvert, AM;Tvedten, HW;Scott, MA
两只猫的高钠血症和一只狗的低钠血症与Bayer H*1血液分析仪测定的红细胞（RBC）指数和红细胞压积（HCT）的人为变化相关。RBC细胞图和直方图显示，在高钠血症猫中，红细胞群向大红细胞、低色素RBC转变，在低钠血症犬中，红细胞群向小红细胞、高色素RBC转变。确立了正常钠血症犬、猫和马中手动红细胞压积（PCV）与分析仪衍生HCT之间差异的参考区间。所有3例患者的PCV和HCT之间的差异均超出参考值。质量控制措施，如测量PCV，并审查细胞图和直方图，对于检测血清钠浓度和渗透压摩尔浓度异常引起的自动血液学测量中的虚假变化至关重要。
Hypernatremia in two cats and hyponatremia in a dog were associated with artifactual changes in red blood cell (RBC) indices and hematocrit (HCT) determined on a Bayer H*1 hematology analyzer. The RBC cytograms and histograms revealed a population shifted towards macrocytic, hypochromic RBC in the hypernatremic cats, and towards microcytic, hyperchromic RBC in the hyponatremic dog. Reference intervals for the difference between manual packed cell volume (PCV) and analyzer-derived HCT in normonatremic dogs, cats and horses were established. The difference between PCV and HCT was outside the reference values for all three patients. Quality control measures, such as measuring PCV, and reviewing cytograms and histograms, are essential for defecting spurious changes in automated hematology measurements caused by abnormalities in serum sodium concentration and osmolality.