Human hippocampal CA1 involvement during allocentric encoding of spatial information.
Human hippocampal CA1 involvement during allocentric encoding of spatial information.
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DOI：
10.1523/jneurosci.0621-09.2009
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发表时间：
2009-08-26
期刊：
影响因子：
--
通讯作者：
Bookheimer SY
中科院分区：
文献类型：
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作者：
Suthana NA;Ekstrom AD;Moshirvaziri S;Knowlton B;Bookheimer SY
我们在环境中导航能力的一个核心组成部分是形成一种以环境为中心的记忆表征，它因此独立于我们在该环境中的起始点。计算模型和啮齿动物的电生理记录表明，海马体的CA1亚区在这种编码类型中起着关键作用；然而，人类空间学习的海马神经基础仍不清楚。我们利用高分辨率功能性磁共振成像（平面内1.6毫米×1.6毫米）和计算展开技术对学习虚拟环境的受试者进行了研究，以便更好地观察海马体神经活动的亚结构变化。我们发现，当受试者学习一个独立于起始点和方向的空间环境时，右侧后CA1亚区是活跃的，并且与表现呈正相关。总之，我们的研究结果表明，CA1亚区参与了我们学习环境的类似地图表征的能力。
A central component of our ability to navigate an environment is the formation of a memory representation that is allocentric and thus independent of our starting point within that environment. Computational models and rodent electrophysiological recordings suggest a critical role for the CA1 subregion of the hippocampus in this type of coding; however, the hippocampal neural basis of spatial learning in humans remains unclear. We studied subjects learning virtual environments using high-resolution functional magnetic resonance imaging (1.6 mm × 1.6 mm in-plane) and computational unfolding to better visualize substructural changes in neural activity in the hippocampus. We show that the right posterior CA1 subregion is active and positively correlated with performance when subjects learn a spatial environment independent of starting point and direction. Altogether, our results demonstrate that the CA1 subregion is involved in our ability to learn a map-like representation of an environment.