REACTOGENICITY, IMMUNOGENICITY, AND EFFICACY OF A CHICK-EMBRYO CELL DERIVED VACCINE FOR ROCKY-MOUNTAIN SPOTTED-FEVER
REACTOGENICITY, IMMUNOGENICITY, AND EFFICACY OF A CHICK-EMBRYO CELL DERIVED VACCINE FOR ROCKY-MOUNTAIN SPOTTED-FEVER
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DOI：
10.1093/infdis/148.5.922
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发表时间：
1983-01-01
影响因子：
6.4
通讯作者：
LEVINE, MM
中科院分区：
文献类型：
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作者：
CLEMENTS, ML;WISSEMAN, CL;LEVINE, MM
在一项安慰剂对照、双盲研究中，评价了通过蔗糖密度梯度离心组织培养生长的立克次体制备的新型福尔马林灭活疫苗的安全性和免疫原性。在52例血清阴性成人疫苗中，88%在第1次接种后，66%在第2次接种后，发生了短暂、轻度（主要是局部）反应，但只有50%对疫苗接种表现出全身免疫应答。6名未接种疫苗的志愿者（对照组）和16名接种疫苗的志愿者用R.立克次体1个月接种疫苗后。疫苗有效率为25%，所有6名对照和16名接种者中的12名发生了典型的落基山斑疹热。与对照组相比，所有疫苗接种者的潜伏期较长，全身症状持续时间较短，发热程度较低。这种疫苗只能部分预防落基山斑疹热，但改善了病情。
A new formalin-inactivated vaccine prepared by sucrose density gradient centrifugation of tissue culture-grown Rickettsia rickettsii was evaluated for safety and immunogenicity in a placebo-controlled, double-blind study. Most of the 52 seronegative adult vaccines, 88% after the 1st and 66% after the 2nd dose, experienced brief, mild (mostly local) reactions, but only 50% exhibited a systemic immune response to vaccination. Six unvaccinated volunteers (controls) and 16 of these vaccinees were challenged with R. rickettsii 1 mo. after vaccination. Vaccine efficacy was 25%; all 6 controls and 12 of 16 vaccinees developed typical Rocky Mountain spotted fever. The incubation period was longer, the duration of constitutional symptoms shorter, and the height of fever lower in all vaccinees than in controls. The vaccine provided only partial protection against Rocky Mountain spotted fever but ameliorated the illness.