Pre- and postnatal developmental changes in hypothalamic and pituitary content of alpha-melanocyte-stimulating hormone and somatostatin in the rat.
Pre- and postnatal developmental changes in hypothalamic and pituitary content of alpha-melanocyte-stimulating hormone and somatostatin in the rat.
复制标题
大鼠下丘脑和垂体α-黑素细胞刺激激素和生长抑素含量的产前和产后发育变化。
DOI：
10.1159/000242037
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发表时间：
1984
期刊：
影响因子：
--
通讯作者：
McCann,SM
中科院分区：
文献类型：
--
作者：
Khorram,O;McCann,SM
本文用放射免疫分析法（RIA）研究了大鼠下丘脑和垂体生长抑素和α-促黑素细胞激素（α-MSH）的发育规律。出生前下丘脑生长抑素含量低，第一次增加发生在出生后第5天。出生前未检测到生长抑素，出生后第6天首次检测到生长抑素。垂体生长抑素的发育模式与下丘脑生长抑素相同。从胎儿和新生儿中分析整个垂体。成人前叶和后叶的分析显示，所有的生长抑素都在后叶。因此，人们认为，在年轻动物的腺体中发现的生长抑素是在神经叶中。α-MSH在胎儿下丘脑中的表达早在出生后16天就已检测到，出生前19天明显增加，出生后10天进一步增加。在检查的第一天，即胎儿期的第16天，很容易检测到的β-MSH含量在整个发育过程中增加。本实验观察了α-MSH对不同年龄大鼠垂体体外释放生长激素的影响。α-MSH对生长激素释放无影响。
The developmental pattern of hypothalamic and pituitary somatostatin and α-melanocyte-stimulating hormone (α-MSH) was studied in the rat by radioimmunoassay (RIA). Prenatally hypothalamic somatostatin was low and the first increase in content occurred on day 5 of the postnatal period. Pituitary somatostatin was undetectable prenatally and was first detected on day 6 postnatally. Pituitary somatostatin showed the same development pattern as hypothalamic somatostatin. Whole pituitaries were analyzed from the fetuses and neonates. Analysis of anterior and posterior lobes from adults revealed that all the somatostatin was in the posterior lobe. Therefore, it is believed that the somatostatin found in the glands of the younger animals was in the neural lobe. α-MSH was detected in the fetal hypothalamus as early as day 16, with a marked increase occurring on day 19 prenatally and a further increase on day 10 postnatally. Pituitary α-MSH content, readily detectable on the first day examined, i.e. day 16 of the fetal period, increased throughout development. The effect of α-MSH on the release of growth hormone in vitro from pituitaries of rats of various ages was tested. α-MSH had no effect on growth hormone release.