Regulation of defensive function on gingival epithelial cells can prevent periodontal disease.
Regulation of defensive function on gingival epithelial cells can prevent periodontal disease.
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DOI：
10.1016/j.jdsr.2017.11.003
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发表时间：
2018-05
期刊：
影响因子：
--
通讯作者：
Kurihara H
中科院分区：
文献类型：
--
作者：
Fujita T;Yoshimoto T;Kajiya M;Ouhara K;Matsuda S;Takemura T;Akutagawa K;Takeda K;Mizuno N;Kurihara H
牙周病是一种与细菌生物膜相关的炎症性疾病，与许多全身性疾病有关。为了在超老龄化社会中促进老年人的健康，需要开发一种新的牙周病预防方法。牙龈上皮作为抵抗细菌入侵的机械屏障和牙周组织中对感染性炎症的天然免疫反应的一部分起着重要作用。细胞间相互作用的紊乱和随后的炎症导致牙周病的发生。因此，我们认为调节宿主的防御功能，上皮屏障和中性粒细胞的活性，可能成为牙周炎预防的新方法。基于这一概念，我们已经发现，几种药物调节牙龈上皮细胞的屏障功能，抑制中性粒细胞在牙龈上皮中的积累。本文介绍了马来酸伊索拉定、阿奇霉素、阿替霉素B和常用中药鱼腥草在体内外对牙龈上皮细胞的上皮屏障和中性粒细胞迁移的作用，为临床应用这些药物预防牙周炎提供支持。
Periodontal disease is a bacterial biofilm-associated inflammatory disease that has been implicated in many systemic diseases. A new preventive method for periodontal disease needs to be developed in order to promote the health of the elderly in a super-aged society. The gingival epithelium plays an important role as a mechanical barrier against bacterial invasion and a part of the innate immune response to infectious inflammation in periodontal tissue. The disorganization of cell–cell interactions and subsequent inflammation contribute to the initiation of periodontal disease. These make us consider that regulation of host defensive functions, epithelial barrier and neutrophil activity, may become novel preventive methods for periodontal inflammation. Based on this concept, we have found that several agents regulate the barrier function of gingival epithelial cells and suppress the accumulation of neutrophils in the gingival epithelium. We herein introduce the actions of irsogladine maleate, azithromycin, amphotericin B, and Houttuynia cordata (dokudami in Japanese), which is commonly used in traditional medicine, on the epithelial barrier and neutrophil migration in gingival epithelial cells in vivo and in vitro, in order to provide support for the clinical application of these agents to the prevention of periodontal inflammation.
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影响因子：
5.8
作者：
Fujita, Tsuyoshi;Kishimoto, Akiyoshi;Kurihara, Hidemi
通讯作者：
Kurihara, Hidemi
影响因子：
4.9
作者：
Asgrimsson, V;Gudjonsson, T;Baldursson, O
通讯作者：
Baldursson, O
影响因子：
5.2
作者：
Dotis, John;Simitsopoulou, Maria;Roilides, Emmanuel
通讯作者：
Roilides, Emmanuel
影响因子：
7.6
作者：
Hiraishi, H.;Haruma, K.;Goto, H.
通讯作者：
Goto, H.
影响因子：
3.5
作者：
Fujita, T.;Firth, J. D.;Putnins, E. E.
通讯作者：
Putnins, E. E.