The role of 18F-FDG PET/CT in differentiating malignant from benign portal vein thrombosis
The role of 18F-FDG PET/CT in differentiating malignant from benign portal vein thrombosis
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DOI：
10.1007/s00261-014-0170-5
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发表时间：
2014-12-01
影响因子：
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通讯作者：
Zuo, Changjing
中科院分区：
文献类型：
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作者：
Hu, Shengping;Zhang, Jian;Zuo, Changjing
在这项回顾性研究中，我们评估了F-18-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（F-18-FDG PET/CT）在鉴别已知恶性肿瘤患者门静脉血栓形成（PVT）中的作用。进行PET/CT扫描的视觉和半定量分析。通过在血栓形成部位绘制感兴趣区域，使用最大标准化摄取值（SUVmax）测量代谢活性。进行受试者工作特征分析以确定SUVmax检测肿瘤性血栓形成的最佳截止值。使用以下标准定义心率失常：（1）目视分析和（2）SUV最大值> 3.35。PET/CT结果与组织病理学结果以及临床和影像学随访相一致，癌性血栓的SUVmax（6.37 +/-A2.67）明显高于良性血栓（2.87 +/-A1.47; P < 0.01）。两种诊断标准的敏感性、特异性和准确性分别为91.5%和93.6%、64.0%和80.0%; F-18-FDGPET/CT半定量分析是鉴别门静脉癌性血栓和良性血栓的一种新方法，以SUVmax > 3.35为最佳临界值。
In this retrospective study, we evaluated the role of F-18-fluorodeoxyglucose positron emission tomography/computed tomography (F-18-FDG PET/CT) in differentiating malignant from benign portal vein thrombosis (PVT) in patients with known malignant tumors.Seventy-two patients with histologically or clinically confirmed PVT and who had undergone F-18-FDG PET/CT were included. Visual and semiquantitative analyses of PET/CT scans were performed. Metabolic activity was measured using the maximum standardized uptake value (SUVmax) by drawing the region of interest at the site of thrombosis. Receiver operating characteristic analysis was conducted to identify the optimal cutoff of SUVmax for detecting neoplastic thrombosis. Malignancy was defined using the following criteria: (1) visual analysis and (2) SUVmax > 3.35. PET/CT results were confirmed with histopathological results and clinical and imaging follow-up.The SUVmax of tumor thrombus (6.37 +/- A 2.67) was significantly higher than that of bland thrombus (2.87 +/- A 1.47; P < 0.01). The sensitivities, specificities, and accuracies for the two criteria were 91.5 % and 93.6; 64.0 and 80.0 %; and 81.9 % and 88.9 %, respectively.F-18-FDG PET/CT is a promising new method for distinguishing between portal venous neoplastic thrombosis and bland thrombosis using semiquantitative analysis, with the optimal cutoff value of SUVmax > 3.35 as a criterion.