Evaluation of responses to immunosuppressive therapy in dogs with suspected non‐regenerative immune‐mediated anaemia: 11 cases (2012‐2018)
Evaluation of responses to immunosuppressive therapy in dogs with suspected non‐regenerative immune‐mediated anaemia: 11 cases (2012‐2018)
复制标题
疑似非再生性免疫介导性贫血犬对免疫抑制治疗反应的评估：11例（2012-2018）
DOI：
10.1111/jsap.13614
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发表时间：
2023
影响因子：
1.6
通讯作者：
Takiguchi M.
中科院分区：
文献类型：
--
作者：
Morishita K.;Sugawara‐Suda M.;Yamazaki J.;Sasaki N.;Nakamura K.;Ohta H.;Takiguchi M.
我们的目的是确定免疫抑制治疗的反应时间，以及在非再生免疫介导的贫血犬中实现红细胞压压增加5%所需的时间。材料与方法入选2012年12月至2018年5月在北海道大学兽医教学医院诊断为非再生免疫介导性贫血的客户拥有的狗。第一个治疗方案包括强的松龙（2 mg/kg/天）和环孢素（高达10 mg/kg/天），持续8周。对第一种方案没有反应的狗进入第二种方案，包括强的松龙和霉酚酸酯（15 mg/kg，每天两次）。网织红细胞计数和红细胞压积每1 ~ 2周监测一次。治疗反应定义为网织红细胞绝对计数大于60×103/μL或红细胞压积增加。结果在研究期间，23只狗符合非再生免疫介导性贫血的纳入标准。由于各种原因，12只狗被排除在本研究之外，并对其余11只狗的治疗反应进行评估。11只狗中有8只观察到治疗反应，中位反应时间为39.5天（范围8至92天）。两名应答者无法继续第一种治疗方案，并由于厌食和恶心（可能由环孢素引起）而切换到第二种治疗方案；停用环孢素可改善症状。对其他6只狗的红细胞压积增加5%所需的时间进行评估，中位数为55.5天（范围为8至135天）。临床意义在这里，我们报告了对非再生免疫介导贫血犬的标准化治疗方案的反应。了解潜在的副作用和预期的治疗结果可能对兽医治疗这种情况有用。
ObjectivesWe aimed to determine the response time to immunosuppressive therapy and time required to achieve a 5% increase in haematocrit among dogs with non‐regenerative immune‐mediated anaemia.Materials and MethodsClient‐owned dogs diagnosed with non‐regenerative immune‐mediated anaemia in Hokkaido University Veterinary Teaching Hospital between December 2012 and May 2018 were enrolled. The first treatment regimen included prednisolone (2 mg/kg/day) and ciclosporin (up to 10 mg/kg/day) for 8 weeks. Dogs that did not respond to the first regimen proceeded to the second regimen comprising prednisolone and mycophenolate mofetil (15 mg/kg, twice a day). Reticulocyte count and haematocrit were monitored every 1 to 2 weeks. Treatment response was defined as an absolute reticulocyte count more than 60×103/μL or increasing haematocrit.ResultsDuring the study period, 23 dogs fulfilled the inclusion criteria for non‐regenerative immune‐mediated anaemia. Twelve dogs were excluded from this study for various reasons and response to therapy was evaluated in the remaining 11 dogs. Treatment responses were observed in 8 of 11 dogs, and the median time to response was 39.5 days (range 8 to 92 days). Two responders were unable to continue the first treatment regimen and were switched to the second regimen owing to anorexia and nausea, possibly induced by ciclosporin; withdrawal of ciclosporin improved their symptoms. The time required to achieve a 5% increase in haematocrit was assessed in the other six dogs, with a median of 55.5 days (range 8 to 135 days).Clinical SignificanceHere we report the response to a standardised treatment protocol in dogs with non‐regenerative immune‐mediated anaemia. Knowledge of potential side effects and expected therapeutic outcomes may be of use for veterinary practitioners treating this condition.