Influence of Indigestible Fibers on Glucose Tolerance
Influence of Indigestible Fibers on Glucose Tolerance
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DOI：
10.2337/diacare.1.2.83
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发表时间：
1978-03
期刊：
影响因子：
16.2
通讯作者：
Louis Monnier;Pham Tc;L. Aguirre;A. Orsetti;J. Mirouze
中科院分区：
文献类型：
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作者：
Louis Monnier;Pham Tc;L. Aguirre;A. Orsetti;J. Mirouze
在8例表现出化学性糖尿病与刺激后低血糖的患者中，我们观察到口服葡萄糖耐量试验（OGTT）的模式得到改善时，不消化纤维添加到口服葡萄糖负荷。与标准OGTT相比，果胶或磷酸纤维素使血糖峰值（以相对于基线的百分比变化表示）特别钝化，但补充纤维素后血糖峰值保持不变。果胶显著延长了达到血糖峰值所需的时间间隔。果胶比磷酸纤维素更能降低血糖升高的速率，而磷酸纤维素又比纤维素更有效。果胶使血糖最低值（以相对于基线的百分比变化表示）变钝，而添加磷酸纤维素或纤维素后，结果无显著差异。另一方面，血浆免疫反应性胰岛素没有显示出任何显着的变化，无论是葡萄糖与或不与上述类型的纤维之一。从这些结果中，可以得出结论，额外的纤维摄入量可能对化学性糖尿病的管理感兴趣。果胶的使用可以减少刺激后低血糖。
In eight patients exhibiting chemical diabetes mellitus with a poststimulative hypoglycemia, we observed that the pattern of the oral glucose tolerance test (OGTT) was improved when indigestible fiber was added to the oral glucose load. As compared with a standard OGTT, the peak blood glucose, expressed as per cent change from baseline, was particularly blunted by pectin or by cellulose phosphate but remained unchanged with cellulose supplementation. The time interval required to reach the blood glucose peak was significantly prolonged with pectin. The rate of blood glucose rise was reduced to a greater extent by pectin than by cellulose phosphate, which in turn was more efficient than cellulose. The blood glucose nadir expressed as per cent change from baseline was blunted by pectin, while the results were not significantly different after addition of either cellulose phosphate or cellulose. On the other hand, the plasma immunoreactive insulin did not show any significant change whether the glucose was given with or without one of the aforementioned types of fiber. From these results, it is concluded that an additional fiber intake may be of interest in the management of chemical diabetes. The use of pectin may diminish the poststimulative hypoglycemia.