The Role of MicroRNAs and Their Targets in Osteoarthritis.
The Role of MicroRNAs and Their Targets in Osteoarthritis.
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DOI：
10.1007/s11926-016-0604-x
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发表时间：
2016-08
影响因子：
5
通讯作者：
Haqqi TM
中科院分区：
文献类型：
--
作者：
Sondag GR;Haqqi TM
microRNA的调控和表达已成为确定多种炎症介导的疾病的调控机制的新兴领域。最近的研究集中在骨关节炎中差异表达的特定microRNA上。此外，还鉴定了这些miRNA在疾病进展中重要的几个靶点。在这篇综述中，我们专注于microRNA的生物发生，调节，检测和定量，重点是细胞定位以及这些概念如何与骨关节炎等疾病过程联系起来。接下来，我们回顾了特定microRNA与骨关节炎相关的某些特征和风险因素（如炎症、肥胖、自噬和软骨稳态）的关系。我们还鉴定了在骨关节炎组织中差异表达但在疾病发病机制中具有未鉴定的靶点和功能的选定microRNA。最后，我们强调了microRNA用于治疗目的的潜在用途，并指出了某些调节microRNA表达的疗法。
MicroRNA regulation and expression has become an emerging field in determining the mechanisms regulating a variety of inflammation-mediated diseases. Recent studies have focused on specific microRNAs that are differentially expressed in case of osteoarthritis. Furthermore, several targets of these miRNAs important in disease progression have also been identified. In this review, we focus on microRNA biogenesis, regulation, detection, and quantification with an emphasis on cellular localization and how these concepts may be linked to disease processes such as osteoarthritis. Next, we review the relationship of specific microRNAs to certain features and risk factors associated with osteoarthritis such as inflammation, obesity, autophagy, and cartilage homeostasis. We also identify selected microRNAs that are differentially expressed in osteoarthritic tissue, but have unidentified targets and functions in the disease pathogenesis. Lastly, we highlight the potential use of microRNAs for therapeutic purposes, and also point to certain remedies that regulate microRNA expression.