Drug-induced phototoxicity evoked by inhibition of human ABC transporter ABCG2: development of in vitro high-speed screening systems
Drug-induced phototoxicity evoked by inhibition of human ABC transporter ABCG2: development of in vitro high-speed screening systems
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DOI：
10.1517/17425255.4.3.255
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发表时间：
2008-03
影响因子：
4.3
通讯作者：
Ai Tamura;R. An;Yuichiro Hagiya;K. Hoshijima;Takashi Yoshida;K. Mikuriya;T. Ishikawa
中科院分区：
文献类型：
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作者：
Ai Tamura;R. An;Yuichiro Hagiya;K. Hoshijima;Takashi Yoshida;K. Mikuriya;T. Ishikawa
背景：光敏性取决于遗传和环境因素。存在于各种植物性食物和食物补充剂中的磷素a可以被小肠吸收。磷素a和卟啉在全身血液循环中的积累可导致光暴露皮肤的光毒性病变。目的：由于人类atp结合盒（ABC）转运体ABCG2被认为在卟啉介导的光敏性中起关键作用，我们旨在开发药物诱导光毒性的体外筛选系统。结论：药物抑制ABCG2或其基因多态性导致的功能损害可导致卟啉稳态的破坏。本文综述了药物引起的光敏性，以及我们对ABCG2在光毒性中的潜在作用的假设。
Background: Photosensitivity depends on both genetic and environmental factors. Pheophorbide a, present in various plant-derived foods and food supplements, can be absorbed by the small intestine. Accumulation of pheophorbide a and porphyrins in the systemic blood circulation can result in phototoxic lesions on light-exposed skin. Objective: As the human ATP-binding cassette (ABC) transporter ABCG2 has been suggested to be critically involved in porphyrin-mediated photosensitivity, we aimed to develop in vitro screening systems for drug-induced phototoxicity. Conclusion: Functional impairment owing to inhibition of ABCG2 by drugs or its genetic polymorphisms can lead to the disruption of porphyrin homeostasis. This review article provides an overview on drug-induced photosensitivity, as well as our hypothesis on a potential role of ABCG2 in phototoxicity.