A diet high in sugar-sweetened beverage and low in fruits and vegetables is associated with adiposity and a pro-inflammatory adipokine profile.
A diet high in sugar-sweetened beverage and low in fruits and vegetables is associated with adiposity and a pro-inflammatory adipokine profile.
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DOI：
10.1017/s0007114518002726
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发表时间：
2018-12
期刊：
影响因子：
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通讯作者：
Xiang AH
中科院分区：
文献类型：
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作者：
Koebnick C;Black MH;Wu J;Shu YH;MacKay AW;Watanabe RM;Buchanan TA;Xiang AH
饮食、肥胖和脂肪因子在糖尿病和心血管疾病中起着重要作用，然而，有限的研究评估了饮食与多种脂肪因子之间的关系。这项横断面研究评估了墨西哥裔美国人的饮食、肥胖和脂肪因子之间的关系。该队列包括1，128名参与者（年龄34.7 ± 8.2岁，BMI 29.5±5.9 kg/m2，73.2%为女性）。通过12个月的食物频率问卷评估饮食摄入量。采用双能X线吸收法，通过BMI、总体脂百分比和躯干脂肪百分比测量肥胖。采用多重试剂盒或ELISA检测脂联素、apelin、CRP、DPP-IV、IL-1β、IL-1 Ra、IL-6、IL-18、瘦素、脂质运载蛋白、MCP-1、β-内酰胺酶、SFRP-4、SFRP-5、TNF-α和内脂素。饮食，肥胖和脂肪因子之间的联合多变量关联进行了分析，使用典型相关校正年龄，性别，能量摄入和亲属关系。中位（IQR）能量摄入量为2，274（1，748，2，847）kcal/d。总的来说，碳水化合物占总摄入量的55%（24%来自糖）。饮食和肥胖之间共有66%的变异，饮食和脂肪因子之间共有34%的变异可以用典型相关解释。饮食成分主要是含糖饮料（SSB）、水果和蔬菜。与高水果和蔬菜摄入量和低SSB摄入量的参与者相比，摄入高SSB和低水果和蔬菜的参与者具有较高的肥胖，CRP，瘦素和MCP-1，但SFRP-5较低。在墨西哥裔美国人中，SSB含量高但水果和蔬菜含量低的饮食导致肥胖和促炎脂肪因子谱
Diet, obesity and adipokines play important roles in diabetes and cardiovascular disease, yet, limited studies have assessed the relationship between diet and multiple adipokines. This cross-sectional study assessed associations between diet, adiposity and adipokines in Mexican Americans. The cohort included 1,128 participants (age 34.7 ± 8.2 y, BMI 29.5±5.9 kg/m2, 73.2% female). Dietary intake was assessed by 12-month food frequency questionnaire. Adiposity was measured by BMI, total percentage body fat, and percentage trunk fat using dual- energy X-ray absorptiometry. Adiponectin, apelin, CRP, DPP-IV, IL-1β, IL-1Ra, IL-6, IL-18, leptin, lipocalin, MCP-1, resistin, SFRP-4, SFRP-5, TNF-α, and visfatin were assayed with multiplex kits or ELISA. Joint multivariate associations between diet, adiposity and adipokines were analyzed using canonical correlations adjusted for age, sex, energy intake, and kinship. The Median (IQR) energy intake was 2,274 (1,748, 2,847) kcal/d. Overall, 55% of total intake was accounted for by carbohydrates (24% from sugar). A total of 66% of the shared variation between diet and adiposity, and 34% of diet and adipokines were explained by the top canonical correlation. The diet component was most represented by sugar-sweetened beverages(SSB), fruit and vegetables. Participants consuming a diet high in SSB and low in fruits and vegetables had higher adiposity, CRP, leptin, and MCP-1, but lower SFRP-5 than participants with high fruit and vegetable and low SSB intake. In Mexican Americans, diets high in SSB but low in fruits and vegetables contribute to adiposity and a pro-inflammatory adipokine profile