Calcineurin knockout mice show a selective loss of small spines.
Calcineurin knockout mice show a selective loss of small spines.
复制标题
钙调神经磷酸酶基因敲除小鼠表现出小刺的选择性丧失。
DOI：
10.1016/j.neulet.2018.02.006
复制
发表时间：
2018
影响因子：
2.5
通讯作者：
Okazaki H
中科院分区：
文献类型：
--
作者：
Okazaki H
钙调神经磷酸酶是长期抑郁症和活动依赖性脊柱萎缩所必需的，在精神分裂症患者中已经发现了钙调神经磷酸酶突变。此外，有条件敲除钙调磷酸酶B（CNB-KO）的小鼠表现出精神分裂症的行为异常。然而，这些小鼠树突棘的变化尚未研究。因此，我们检查了CNB-KO小鼠的树突棘，并观察到前额叶和视觉皮质中小棘的显著减少和大棘的增加。CNB-KO对棘大小的影响相对中等，可能是由于树突棘本身存在自发波动（动力学）。因此，CNB-KO小鼠表现出与最近报道的精神分裂症患者相似的脊柱表型。
Calcineurin is required for long-term depression and activity-dependent spine shrinkage, and calcineurin mutations have been identified in patients with schizophrenia. Moreover, mice with conditional knockout of calcineurin B (CNB-KO) exhibit behavioral abnormalities suggestive of schizophrenia. Changes in the dendritic spines of these mice, however, have not been investigated. We therefore examined the dendritic spines of CNB-KO mice, and observed a significant reduction in small spines and an increase in large spines in the prefrontal and visual cortices. The effect of CNB-KO on the spine sizes was relatively moderate, possibly due to the presence of spontaneous fluctuations (dynamics) in the dendritic spines themselves. Thus, CNB-KO mice showed a spine phenotype similar to those recently reported in patients with schizophrenia.