Elevated risk of colorectal cancer associated with the AA genotype of the cyclin D1 A870G polymorphism in an Indian population
Elevated risk of colorectal cancer associated with the AA genotype of the cyclin D1 A870G polymorphism in an Indian population
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DOI：
10.1007/s00432-005-0039-7
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发表时间：
2006-03-01
影响因子：
3.6
通讯作者：
Tokudome, S
中科院分区：
文献类型：
--
作者：
Jiang, J;Wang, JW;Tokudome, S
目的：探讨印度人群中常见的细胞周期蛋白D1（CCND 1）A870 G多态性是否是结直肠癌（CRC）的危险因素。方法：采用PCR-RFLP方法对301例初治结直肠癌患者和291例健康对照者进行基因分型。比较病例组和对照组的基因型频率，并研究基因型与结直肠癌的关系。结果如下：CCND 1 870 A等位基因在结直肠癌患者中的频率高于对照组（0.63 vs.0.56，P=0.01），在校正年龄、性别、吸烟习惯、家族史、家庭收入和肉类、鱼类、蔬菜和水果的消费后，观察到AA基因型比GG+AG基因型的风险增加（OR=1.56; 95%CI：1.10-2.21）。结肠癌（OR=1.96; 95% CI：1.08-3.57）和直肠癌（OR=1.51; 95% CI：1.04-2.19）的危险性也增加。基因型与结直肠癌诊断年龄之间无相关性（GG、AG和AA基因型分别为49.9、48.7和49.4岁; P=0.84）。多变量分析还显示，在高肉类摄入的患者中，AA基因型与肥胖有更强的正相关性（OR=2.67，95%CI：1.29-5.51），且在高蔬菜消费者中，GG+AG基因型也被发现有显著的负相关（2-3份/天的OR=0.46; 95%CI：0.27-0.79;> 3份/天的OR=0.31; 95%CI：0.18-0.53）和鱼摄入量（OR=0.48; 95%CI：0.28-0.82）。结论：这些数据支持CCND 1 A870 G多态性可能增加印度人群结直肠癌风险的假设。
Purpose: To investigate whether the common cyclin D1 (CCND1) A870G polymorphism is a risk factor for colorectal cancer (CRC) in an Indian population. Methods: In this study, 301 newly diagnosed CRC patients and 291 healthy control subjects were genotyped by the PCR-RFLP method. Genotype frequencies were compared between cases and controls, and the association of genotypes with CRC was studied. Results: The CCND1 870 A allele was more frequently observed in CRC patients than controls (0.63 vs. 0.56, P=0.01), and after adjustment for age, sex, smoking habits, family history, family income and the consumption of meat, fish, vegetables and fruit, an increased risk was observed for the AA genotype compared to the GG+AG genotype (OR=1.56; 95% CI: 1.10-2.21). The increased risk were also found for colon (OR=1.96; 95% CI: 1.08-3.57) and rectal cancer (OR=1.51; 95% CI: 1.04-2.19). No correlation was observed between genotypes and age of diagnosis of CRC (49.9, 48.7 and 49.4 years for the GG, AG and AA genotypes, respectively; P=0.84). Multivariate analysis also revealed a stronger positive association with the AA genotype among patients with high meat intake (OR=2.67; 95% CI: 1.29-5.51), and particularly significant inverse associations with the GG+AG genotypes were also found for those with high vegetable consumption (OR=0.46; 95% CI: 0.27-0.79 of 2-3 servings/day, and OR=0.31; 95% CI: 0.18-0.53 for > 3 servings/day) and fish intake (OR=0.48; 95% CI: 0.28-0.82). Conclusion: These data support the hypothesis that the CCND1 A870G polymorphism may increase the risk of CRC in our Indian population.