Application of ADC measurement in characterization of renal cell carcinomas with different pathological types and grades by 3.0 T diffusion-weighted MRI
Application of ADC measurement in characterization of renal cell carcinomas with different pathological types and grades by 3.0 T diffusion-weighted MRI
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DOI：
10.1016/j.ejrad.2012.04.028
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发表时间：
2012-11-01
影响因子：
3.3
通讯作者：
Zhang, Hongtu
中科院分区：
文献类型：
--
作者：
Yu, Xiaoduo;Lin, Meng;Zhang, Hongtu
目的：为探讨3.0 T扩散加权成像（DWI）获得的表观扩散系数（ADC）值在不同病理亚型和分级肾细胞癌（RCC）中的应用价值，材料与方法：对137例经DWI确诊的RCC患者进行分析。经手术病理证实。在B值为0和800 s/mm（2）时获得DWI图像。测量肿瘤实性区及对侧正常肾实质相应区域的ADC值，并进行统计学分析。肾癌的平均ADC值显著降低正常肾实质组织的平均流速（1.381 ± 0.444 × 10（-3）mm（2）/s）明显高于正常肾实质组织（2.232 ± 0.221 × 10（-3）mm（2）/s）（P < 0.001）。不同分级的透明细胞肾癌（CCRCC）与非透明细胞肾癌（non-CCRCC）之间ADC值差异有统计学意义。结论：3.0TDWI上ADC值的测量可为肾癌的诊断提供有用的信息，有助于鉴别肾癌与正常肾组织，并有助于区分不同病理亚型和分级的肾癌。(C)由Elsevier爱尔兰有限公司出版。
Purpose: To test the feasibility of apparent diffusion coefficient (ADC) value obtained with 3.0 T diffusion-weighted imaging (DWI) in the characterization of renal cell carcinomas (RCC) with different pathological subtypes and grades.Materials and methods: A total of 137 patients who were diagnosed with RCC and underwent DWI were included in this study. The diagnosis was confirmed by pathological examination of surgical specimens. Images of DWI were obtained with b values of 0 and 800 s/mm(2). The ADC values in the solid area of tumors and in the corresponding regions of contralateral normal renal parenchyma were measured and analyzed statistically.Results: The mean ADC value was significantly lower in RCC (1.381 +/- 0.444 x10(-3)mm(2)/s) than in normal renal parenchyma (2.232 +/- 0.221 x 10(-3)mm(2)/s) (P < 0.001). The ADC value was also statistically different between clear cell RCC (CCRCC) and non-CCRCC, and between different grades of CCRCC except grade I vs II and grade III vs IV.Conclusion: ADC measurement on 3.0 T DWI provides useful information in diagnostic work-up of RCC in terms of differentiation of RCC and normal renal parenchyma, and characterization of RCC with different pathological subtypes and grades. (C) 2012 Published by Elsevier Ireland Ltd.