Nontarget screening of the markers of synthetic cannabinoids in urine using HPLC–MS/MS
Nontarget screening of the markers of synthetic cannabinoids in urine using HPLC–MS/MS
复制标题
使用 HPLC-MS/MS 对尿液中合成大麻素标记物进行非靶向筛查
DOI：
10.1134/s1061934815140087
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发表时间：
2015
影响因子：
1.1
通讯作者：
A. Temerdashev
中科院分区：
文献类型：
--
作者：
A. Labutin;A. Temerdashev
提出了一种生物样品中合成大麻素及其代谢物的非靶点筛选方法。这是基于样品中分析物的基本结构保持不变。讨论的两种方法包括借助高分辨率质谱学鉴定已知的化合物代谢物和对最常见的精神活性化合物类的特征产物离子进行目标筛选。使用AM(N)-2201和AB-PINACA等合成大麻素的患者的真实体液样本检验了建议方法的适用性。
A nontarget screening method for the determination of synthetic cannabinoids and their metabolites in biological samples was proposed. It was based on the preservation of the basic structure of the analytes in samples. The two approaches discussed included the identification of known compound metabolites with the aid of high-resolution mass spectra and the target screening of characteristic product ions of the most common classes of psychoactive compounds. The applicability of the proposed approach was examined with the real samples of biological fluids of patients who used synthetic cannabinoids such as AM(N)-2201 and AB-PINACA.