Synthesis of highly functionalized dextran alkyl carbonates showing nanosphere formation
Synthesis of highly functionalized dextran alkyl carbonates showing nanosphere formation
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DOI：
10.1016/j.carbpol.2010.09.013
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发表时间：
2011-01-30
影响因子：
11.2
通讯作者：
Heinze, Thomas
中科院分区：
文献类型：
--
作者：
Wondraczek, Holger;Elschner, Thomas;Heinze, Thomas
使用不同的酰化剂合成了高度取代的葡聚糖烷基碳酸酯。系统研究了反应介质和烷基链长度对反应效率的影响。此外，氟甲酸酯被成功地用作高效且易于处理的试剂，用于合成葡聚糖烷基碳酸酯。通过NMR和IR光谱清楚地描述了所得产物。葡聚糖酯形成尺寸低于 300 nm 的球形纳米颗粒，可用于递送治疗剂或显像剂。 (C) 2010 Elsevier Ltd. 保留所有权利。
Highly substituted dextran alkyl carbonates were synthesized applying different acylating agents. The influence of the reaction media and the alkyl chain length on the reaction efficiency was systematically studied. Moreover, fluoroformates were successfully adapted as highly efficient and easy to handle reagents for the synthesis of dextran alkyl carbonates. The products obtained were clearly described by means of NMR- and IR spectroscopy. The dextran esters form spherical nanoparticles of a size below 300 nm that might be applied for delivery of therapeutic- or imaging agents. (C) 2010 Elsevier Ltd. All rights reserved.