Intestinal lymphatic transport for drug delivery.
Intestinal lymphatic transport for drug delivery.
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DOI：
10.1016/j.addr.2011.05.019
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发表时间：
2011-09-10
影响因子：
16.1
通讯作者：
Alton KB
中科院分区：
文献类型：
--
作者：
Yáñez JA;Wang SW;Knemeyer IW;Wirth MA;Alton KB
Intestinal lymphatic transport has been shown to be an absorptive pathway following oral administration of lipids and an increasing number of lipophilic drugs, which once absorbed, diffuse across the intestinal enterocyte and while in transit associate with secretable enterocyte lipoproteins. The chylomicron-associated drug is then secreted from the enterocyte into the lymphatic circulation, rather than the portal circulation, thus avoiding the metabolically-active liver, but still ultimately returning to the systemic circulation. Because of this parallel and potentially alternative absorptive pathway, first-pass metabolism can be reduced while increasing lymphatic drug exposure, which opens the potential for novel therapeutic modalities and allows the implementation of lipid-based drug delivery systems. This review discusses the physiological features of the lymphatics, enterocyte uptake and metabolism, links between drug transport and lipid digestion/re-acylation, experimental model (in vivo, in vitro, and in silico) of lymphatic transport, and the design of lipid- or prodrug-based drug delivery systems for enhancing lymphatic drug transport.
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影响因子：
4.1
作者：
Bagchus, WM;Hust, R;Houwing, NS
通讯作者：
Houwing, NS
DOI：
10.1016/s1388-1981(99)00200-0
发表时间：
2000-01-31
影响因子：
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通讯作者：
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BLOOM, B;CHAIKOFF, IL;REINHARDT, WO
通讯作者：
REINHARDT, WO