Radial nerve injury causes long-lasting forelimb sensory impairment and motor dysfunction in rats.
Radial nerve injury causes long-lasting forelimb sensory impairment and motor dysfunction in rats.
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DOI：
10.1097/pr9.0000000000000957
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发表时间：
2021-09
期刊：
影响因子：
4.8
通讯作者：
Hays SA
中科院分区：
文献类型：
--
作者：
Adcock KS;Hulsey DR;Danaphongse T;Haider Z;Morrison RA;Kilgard MP;Hays SA
大鼠桡神经损伤产生持久的感觉运动障碍和皮质功能障碍，这与神经损伤患者的临床表型一致。在美国，周围神经损伤是终身残疾的常见原因。虽然病因各异，但大多数创伤性神经损伤发生在上肢，包括桡神经损伤。结合周围损伤的良好描述的影响，神经损伤伴随着中枢神经系统的变化。全面了解神经损伤的功能后果是必要的，以开发新的治疗干预措施。我们试图描述大鼠桡神经损伤后感觉和运动功能以及中枢神经生理学的变化。为了评估前肢的躯体感觉功能，我们评估了桡神经损伤后10周和16周大鼠的机械退缩阈值、自发前肢使用和冷敏感性。为了评估运动功能，我们评估了神经损伤后长达16周的前肢旋后任务的表现。运动和躯体感觉皮层的生理变化分别采用皮层内微刺激和多单位记录进行评估。我们的研究结果表明，桡神经损伤导致长期的感觉和运动功能障碍。这些行为缺陷伴随着躯体感觉和运动皮层的异常皮层活动。我们的研究结果提供了一种新的功能缺陷的表征，与桡神经损伤患者的临床表型一致，并为未来的研究提供了一个框架，以评估潜在的干预措施。
Radial nerve injury in rats produces lasting sensorimotor impairments and cortical dysfunction that is consistent with the clinical phenotype in nerve-injured patients. Peripheral nerve injury is a common cause of lifelong disability in the United States. Although the etiology varies, most traumatic nerve injuries occur in the upper limb and include damage to the radial nerve. In conjunction with the well-described effects of peripheral damage, nerve injuries are accompanied by changes in the central nervous system. A comprehensive understanding of the functional consequences of nerve injury is necessary to develop new therapeutic interventions. We sought to characterize changes in sensory and motor function and central neurophysiology after radial nerve injury in rats. To evaluate somatosensory function in the forelimb, we assessed mechanical withdrawal threshold, spontaneous forelimb use, and cold sensitivity in rats 10 and 16 weeks after radial nerve injury. To evaluate motor function, we assessed performance on a forelimb supination task for up to 16 weeks after nerve injury. Physiological changes in the motor and somatosensory cortex were assessed using intracortical microstimulation and multiunit recordings, respectively. Our results indicate that radial nerve injury causes long-lasting sensory and motor dysfunction. These behavioral deficits are accompanied by abnormal cortical activity in the somatosensory and motor cortex. Our results provide a novel characterization of functional deficits that are consistent with the clinical phenotype in patients with radial nerve injury and provide a framework for future studies to evaluate potential interventions.