Metal ion release from metal implants
Metal ion release from metal implants
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金属植入物的金属离子释放情况
DOI：
10.1016/j.msec.2004.08.018
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发表时间：
2004-12-01
期刊：
影响因子：
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通讯作者：
Hanawa, T
中科院分区：
文献类型：
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作者：
Hanawa, T
本文综述了不锈钢、钴铬合金、钛及钛合金等金属材料植入人体后的金属离子释放情况。金属材料表面的氧化膜作为离子释放的抑制剂起着重要的作用，并随着体内离子释放的变化而变化。低浓度的溶解氧、无机离子、蛋白质和细胞都可能加速金属离子的释放。破坏后表面氧化膜的再生时间也决定了释放离子的量。此外，在金属材料的磨损和微振磨损过程中会发生特定元素的优先释放。金属离子释放到生物流体中的行为受电化学规律控制。释放的金属离子并不总是与生物分子结合联合收割机而表现出毒性，因为活性离子立即与水分子或离子附近的阴离子结合联合收割机以形成氧化物、氢氧化物或无机盐。因此，离子将与生物分子联合收割机结合以引起细胞毒性、过敏和其它生物影响的可能性很小。(C)2004 Elsevier B.V.保留所有权利。
Metal ion release from metallic materials, e.g. stainless steel, cobalt-chromium alloy, titanium, and titanium alloys, implanted into human body was reviewed in this paper. Surface oxide films on metallic materials play an important role as an inhibitor of ion release and they change with the release in vivo. Low concentration of dissolved oxygen, inorganic ions, proteins, and cells may accelerate the metal ion release. The regeneration time of the surface oxide film after disruption also governs the amount of released ion. In addition, preferential release of specific elements during wear and fretting of metallic materials occurs. The behavior of metal ion release into biofluid is governed by the electrochemical rule. Released metal ions do not always combine with biomolecules to appear toxicity because active ion immediately combine with a water molecule or an anion near the ion to form an oxide, hydroxide, or inorganic salt. Thus, there is only a small chance that the ion will combine with biomolecules to cause cytotoxicity, allergy, and other biological influences. (C) 2004 Elsevier B.V. All rights reserved.