HISTOINCOMPATIBILITY AND MATERNAL IMMUNOLOGICAL STATUS AS DETERMINANTS OF FETOPLACENTAL WEIGHT AND LITTER SIZE IN RODENTS
HISTOINCOMPATIBILITY AND MATERNAL IMMUNOLOGICAL STATUS AS DETERMINANTS OF FETOPLACENTAL WEIGHT AND LITTER SIZE IN RODENTS
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DOI：
10.1084/jem.142.1.180
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发表时间：
1975-01-01
影响因子：
15.3
通讯作者：
BILLINGHAM, RE
中科院分区：
文献类型：
--
作者：
BEER, AE;SCOTT, JR;BILLINGHAM, RE
对小鼠、仓鼠和大鼠的近交系进行的研究表明，在种间交配之后，怀孕的雌性对其概念的同种抗原的现在熟悉的隐蔽反应可能在两个方面有利于后者；首先，它对胎盘重量有显著影响，并间接影响胎儿的出生体重——异体胎盘倾向于比同基因胎盘重，并且母体特异性地对外来父系组织抗原进行了免疫，其胎儿的胎盘比正常女性重。另一方面，特异性耐受的母亲产生较小的F1杂交胎胎盘（fp）单位。传统观点认为F1杂交种和纯合子后代出生体重的差异是由于杂种活力造成的，但这一观点受到了挑战，因为研究发现，将DA和（DA乘以F1）F1杂交种囊胚移植到遗传耐受（DA乘以F1）F1杂交种大鼠的子宫中产生了相似重量的fp单位，母体对同种异体移植胚胎的免疫反应可能在这里起了重要作用。母体对胎儿同种异体抗原的反应在某种程度上促进了卵泡细胞单位的生长，这一假设得到了进一步的支持，因为在异种交配前切除雌性的主动脉旁淋巴结（引流子宫角）会导致比假手术的雌性更小的卵泡细胞单位。在一个大鼠品系组合中发现，用血清对雌性F1杂交胚胎进行被动免疫可促进后者的生长，这表明可能涉及体液免疫而不是细胞免疫。其次，在研究的三个物种中，观察到胚胎与其母亲之间的遗传差异显著提高了其着床和发育到足月的机会。
Studies conducted upon inbred strains of mice, hamsters and rats have shown that following the interstrain matings the now familiar covert reactivity of pregnant females to the alloantigens of their conceptuses may benefit the latter in two ways; firstly, it exerts a significant influence upon placental weight, and indirectly upon the birth weight of the fetus-allogeneic placentas tending to be heavier than syngeneic placentas, and mothers specifically presensitized against alien paternal tissue antigens gestate fetuses with heavier placentas than normal females. Specifically tolerant mothers, on the other hand, produce smaller, F1 hybrid, fetoplacental (fp) units. The classic notion that the disparity between the birth weights of F1 hybrid and homozygous offspring is due to hybrid vigor has been challenged by the finding that DA and (DA times F1)F1 hybrid blastocysts transferred to the uteri of genetically tolerant (DA times F1)F1 hybrid rats produce fp units of similar weight Maternal immunological reactivity against the fetus qua allograft may make a significant contribution here. Additional support for the premise that maternal reactivity against fetal alloantigens in some way promotes the growth of the fp unit was afforded by the finding that excision of the para-aortic lymph nodes (which drain the uterine horns) from females before interstrain matings resulted in smaller fp units than in females subjected to sham operations. The finding with one rat strain combination that passive immunization of females with serum against their F1 hybrid conceptuses promoted the growth of the latter suggests that a humoral rather than a cellular immunity may be involved. Secondly, in the three species studied, it was observed that genetic disparity between a conceptus and its mother significantly improved its chances of implantation and development to term.