The protective effect of adenosine A2A receptor antagonism in cerebral ischemia
The protective effect of adenosine A2A receptor antagonism in cerebral ischemia
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DOI：
10.1179/016164105x21913
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发表时间：
2005-03-01
影响因子：
1.9
通讯作者：
Melani, A
中科院分区：
文献类型：
--
作者：
Pedata, F;Gianfriddo, M;Melani, A
目的：方法：将一根涂有硅胶的尼龙单丝经颈外动脉阻断大鼠右侧大脑中动脉（MCA），造成局灶性脑缺血模型。结果：腺苷A（2A）拮抗剂对大鼠局灶性脑缺血具有保护作用。该方法提供了评估保护免受兴奋性氨基酸流出和急性运动障碍的可能性，即在清醒大鼠缺血后的第一个小时内对侧转向缺血侧。几个小时后，一个明确的神经功能缺损和坏死的神经元damage can be evaluated.Discussion：我们的研究结果表明，A2A拮抗作用可能是保护从最早到几个小时后的缺血事件。
Objectives: We reviewed our most recent work on the protective effect of adenosine A(2A) antagonism in cerebral ischemia.Methods: Focal ischemia was produced in rats by introducing a nylon monofilament pre-coated with silicone through the external carotid artery to occlude the right MCA at its origin.Results:A(2A) antagonism was foundprotective in the model of permanent focal ischemia induced by the monofilament technique. This methodology provides the possibility of evaluating the protection against the outflow of excitatory amino acids and against an acute motor disturbance, i.e. contralateral turning to the ischemic side in the first hours after ischemia in awake rats. Hours later, a definite neurological deficit and necrotic neuronal damage can be evaluated.Discussion: Our results suggest that A2A antagonism may be protective from the earliest up to several hours after the ischemic event.