Development of Quantitative Chiral Recognition Mass Spectrometry.
Development of Quantitative Chiral Recognition Mass Spectrometry.
复制标题
定量手性识别质谱法的发展。
DOI：
10.5702/massspec.50.311
复制
发表时间：
2002
期刊：
影响因子：
--
通讯作者：
M. Sawada
中科院分区：
文献类型：
--
作者：
M. Sawada
The developments of our quantitative chiral recognition studies in the host-guest complexations between chiral crown ethers and chiral amino acid esters by FAB, ESI, and MALDI mass spectrometry have been described. Both the enantiomer labeled (EL)-guest method and the EL-host method, which had been previously proposed by us, were successfully advanced. The relative peak intensity (IRIS) values of the diastereomeric host-guest complex ions appeared in mass spectra were especially noted, and their use to chiral recognition was illustrated. Generally, the former method was used to chiral recognition ability-determination of a given host, and the latter one was used to enantiomeric excess (e.e.)-determination of a given guest. Through the manuscript, emphasis has been put on the finding that one can detect correctly the concentration ratio of the two diastereomeric host-guest complex ions formed in a matrix solution by FAB mass spectrometry and then, that FABMS is a powerful tool for detecting chiral host-guest interactions in the host-guest complexation systems. Recent ,e.e.-determination methods by ESI mass spectrometry etc. were also summarized.
DOI：
10.1073/pnas.96.12.6591
发表时间：
1999-06-08
影响因子：
11.1
作者：
Oda, Y;Huang, K;Chait, BT
通讯作者：
Chait, BT