A Lattice Boltzmann Method for Simulating the Separation of Red Blood Cells at Microvascular Bifurcations
A Lattice Boltzmann Method for Simulating the Separation of Red Blood Cells at Microvascular Bifurcations
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DOI：
10.1088/0256-307x/29/2/024703
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发表时间：
2012-02-01
影响因子：
3.5
通讯作者：
He Ying
中科院分区：
文献类型：
--
作者：
Shen Zai-Yi;He Ying
提出了一种红细胞分离的计算机模拟方法。红细胞的变形能力由基于最小能量原理的弹簧网络模型表示。在流体流动的计算中，采用格子Boltzmann方法求解Navier-Stokes方程。采用浸没边界法进行流体-膜相互作用的耦合。为了验证我们的方法，红细胞在剪切流中的运动进行了模拟。再现了实验中观察到的红细胞典型运动，包括坦克踩踏，摆动和翻滚。模拟了8个红细胞在分叉处的运动，当两个子血管具有不同的比例时。结果表明，当子血管直径的比值变小时，红细胞在两个血管中的分布变得更加不均匀。
A computational simulation for the separation of red blood cells (RBCs) is presented. The deformability of RBCs is expressed by the spring network model, which is based on the minimum energy principle. In the computation of the fluid flow, the lattice Boltzmann method is used to solve the Navier-Stokes equations. Coupling of the fluid-membrane interaction is carried out by using the immersed boundary method. To verify our method, the motions of RBCs in shear flow are simulated. Typical motions of RBCs observed in the experiments are reproduced, including tank-treading, swinging and tumbling. The motions of 8 RBCs at the bifurcation are simulated when the two daughter vessels have different ratios. The results indicate that when the ratio of the daughter vessel diameter becomes smaller, the distribution of RBCs in the two vessels becomes more non-uniform.