Global research trends on the links between gut microbiota and cancer immunotherapy: A bibliometric analysis (2012-2021).
Global research trends on the links between gut microbiota and cancer immunotherapy: A bibliometric analysis (2012-2021).
复制标题
肠道微生物群与癌症免疫治疗之间联系的全球研究趋势：文献计量分析（2012-2021）
DOI：
10.3389/fimmu.2022.952546
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发表时间：
2022
影响因子：
7.3
通讯作者：
中科院分区：
文献类型：
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作者：
背景肠道微生物群（GM）和癌症免疫治疗（CI）之间存在串扰。本研究旨在通过文献计量学分析，识别与GM/CI相关的高被引论文，探讨GM/CI研究的现状和发展趋势。方法于2022年7月4日对2012 - 2021年GM/CI出版物进行文献检索。文章标题、期刊、作者、机构、国家、总引文、关键词和其他信息摘自Web of Science Core Collection（WoSCC）的Science Citation Index Expanded（SCIE）。采用R软件包和VOSviewer中的文献计量表进行文献计量分析。结果共检索到665篇文献。论文数量在过去十年中迅速增加，特别是在2018年之后。美国和中国在这一领域的出版物最多，贡献最大。德克萨斯大学MD安德森癌症中心和巴黎萨克雷大学在GM/CI方面绝对处于领先地位。最有影响力的作者是Zitvogel L和Routy B。Frontiers in Immunology的出版物最多，Science的总引用次数最多。历史直接引文分析解释了GM/CI的历史演变。高被引论文和高频关键词说明了全球机制/传播和信息工作的现状和趋势。研究发现了4个方面的问题，包括GM和抗生素在CI中的作用、GM靶向治疗改善CI结局的方法、GM影响CI的机制以及ICI在黑色素瘤中的应用。“肿瘤微生物组”、“质子泵抑制剂”和“预后”可能是未来几年新的关注焦点。结论通过对全球GM/CI相关性研究文献的筛选，分析其文献计量学特征，找出GM/CI领域被引用最多的论文，了解全球GM/CI研究的现状、热点和趋势，为研究者和从业者提供参考。
Background There is a crosstalk between gut microbiota (GM) and cancer immunotherapy (CI). The purpose of this study is to use bibliometric analysis to identify the highly cited papers relating to GM/CI and explore the research status and development trends of the GM/CI research. Methods A literature search regarding GM/CI publications from 2012 to 2021 was undertaken on July 4, 2022. The article titles, journals, authors, institutions, countries, total citations, keywords, and other information were extracted from the Science Citation Index Expanded (SCIE) of Web of Science Core Collection (WoSCC). The Bibliometrix of R package and VOSviewer were used for bibliometric analysis. Results A total of 665 papers were extracted. The number of papers has increased rapidly over the past decade, especially after 2018. The United States and China had the most publications and made great contributions to this field. Th5e Univ Texas MD Anderson Canc Ctr and Univ Paris Saclay were absolutely in the leading position in GM/CI. The most influential authors were Zitvogel L and Routy B. Frontiers in Immunology had the most publications and Science had the most total citations. Historical direct citation analysis explained the historical evolution in GM/CI. Highly cited papers and high-frequency keywords illustrated the current status and trends of GM/CI. Four clusters were identified and the important topics included the role of GM and antibiotics in CI, the methods of targeting GM to improve CI outcomes, the mechanism by which GM affects CI and the application of ICIs in melanoma. “Tumor microbiome”, “proton pump inhibitors” and “prognosis” may be the new focus of attention in the next few years. Conclusion This study filtered global publications on GM/CI correlation and analyzed their bibliometric characteristics, identified the most cited papers in GM/CI, and gained insight into the status, hotspots and trends of global GM/CI research, which may inform researchers and practitioners of future directions.