LIPID PEROXIDE LEVELS OF SERUM LIPOPROTEIN FRACTIONS OF DIABETIC-PATIENTS
LIPID PEROXIDE LEVELS OF SERUM LIPOPROTEIN FRACTIONS OF DIABETIC-PATIENTS
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DOI：
10.1016/0006-2944(81)90096-x
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发表时间：
1981-01-01
期刊：
影响因子：
--
通讯作者：
YAGI, K
中科院分区：
文献类型：
--
作者：
NISHIGAKI, I;HAGIHARA, M;YAGI, K
据报道，糖尿病患者的血浆脂质过氧化物[LP]水平显著高于对照组，糖尿病合并血管病变患者的水平显著高于糖尿病不合并血管病变患者。31例糖尿病合并血管病变和视网膜病变患者（18例），其中25例血糖控制不佳（空腹血糖≥ 100 mg/L），血清脂蛋白LP水平（1.5mg/L）明显高于对照组（1.5mg/L）。140毫克/分升），检查有关的脂质代谢的一些异常特征。糖尿病患者血清LP水平显著高于正常人（P < 0.005）。糖尿病患者血清中LP水平的增加是由于HDL [高密度脂蛋白]部分中的增加。糖尿病患者血清中甘油三酯、胆固醇和总脂含量明显高于正常人。糖尿病患者血清中HDL和低密度脂蛋白组分中的甘油三酯含量明显高于正常人血清中的相应组分，反映了糖尿病患者脂质代谢的异常。大多数循环HDL颗粒是脂蛋白代谢的终产物，其部分地通过从肝和肠分泌的前体与细胞膜的脂质的相互作用在外周组织的血浆和细胞间隙中形成。由于HDL颗粒可以反映膜的状态，因此在考虑糖尿病患者的膜损伤时应强调HDL组分中观察到的LP水平的增加。
Plasma lipid peroxide [LP] levels of diabetic patients reportedly were significantly higher than those of control subjects and the levels in diabetics with angiopathy were markedly higher than those in diabetics without angiopathy. The LP levels of serum lipoprotein fractions of 31 diabetics with angiopathy and retinopathy (18), 25 of whom were poorly controlled (fasting blood sugar .gtoreq. 140 mg/dl), were examined in relation to some abnormal features of lipid metabolism. Serum LP levels of diabetics were significantly (P < 0.005) higher than those of normal subjects. The increase in LP levels in the sera of diabetics is due to that in the HDL [high density lipoprotein] fraction. The amounts of triglyceride, cholesterol and total lipids in diabetic serum are significantly higher than those in normal serum. The amounts of triglyceride in the HDL and low density lipoprotein fractions of diabetic serum were significantly higher than those in the same fractions of normal serum, reflecting abnormal lipid metabolism in diabetics. Most of the circulating HDL particles are the end products of lipoprotein metabolism, formed in the plasma and intercellular space of peripheral tissues partly through the interaction of precursors secreted from the liver and intestine with lipids of cell membranes. As the HDL particles may reflect the states of the membranes, the observed increase in LP levels in the HDL fraction should be emphasized in considering the membrane damage in diabetic patients.