The pursuit of cryptococcal pathogenesis: heterologous hosts and the study of cryptococcal host-pathogen interactions.
The pursuit of cryptococcal pathogenesis: heterologous hosts and the study of cryptococcal host-pathogen interactions.
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DOI：
10.1111/j.1567-1364.2006.00056.x
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发表时间：
2006-06
影响因子：
3.2
通讯作者：
Roanna London;Benjamin S. Orozco;E. Mylonakis
中科院分区：
文献类型：
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作者：
Roanna London;Benjamin S. Orozco;E. Mylonakis
病原体与人类宿主相互作用的分子机制的分析最常使用哺乳动物感染模型进行。然而，先前显示参与哺乳动物感染新型隐球菌的几个毒力相关基因也被证明在这些病原体与无脊椎动物的相互作用中发挥作用，如卡氏阿米巴、秀丽隐杆线虫、盘状网柄线虫、黑腹果蝇和大蜡螟。使用这些模式宿主的宿主-病原体相互作用的研究允许突变体库的快速筛选，并且可以用于微生物毒力和宿主反应的进化保留方面的研究。
Analysis of the molecular mechanisms by which a pathogen interacts with the human host is most commonly performed using a mammalian model of infection. However, several virulence-related genes previously shown to be involved in mammalian infection with Cryptococcus neoformans have also been shown to play a role in the interaction of these pathogens with invertebrates, such as Acanthamoeba castellanii, Caenorhabditis elegans, Dictyostelium discoideum, Drosophila melanogaster and Galleria mellonella. The study of host-pathogen interactions using these model hosts has allowed rapid screening of mutant libraries and can be used for the study of evolutionarily preserved aspects of microbial virulence and host response.