MOSSBAUER AND NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPIC STUDIES ON MYOCRISIN, SOLGANOL, AURANOFIN, AND RELATED GOLD(I) THIOLATES
MOSSBAUER AND NUCLEAR MAGNETIC-RESONANCE SPECTROSCOPIC STUDIES ON MYOCRISIN, SOLGANOL, AURANOFIN, AND RELATED GOLD(I) THIOLATES
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DOI：
10.1039/dt9840001609
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发表时间：
1984-01-01
期刊：
影响因子：
--
通讯作者：
PARISH, RV
中科院分区：
文献类型：
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作者：
ALSAADY, AKH;MOSS, K;PARISH, RV
已经制备了大量硫醇金(I)，[AU(SR)]，其中R基团是烷基、芳基、羧酸、氨基酸或杂环。大多数在所有常见溶剂中高度不溶，但 [Au(SC6H4R''-p)] (R'' = Et、Pri、Bus 或 But) 溶解在有机溶剂中。可溶性化合物的 1H 和 13C NMR 谱显示了多组信号，这些信号在高温下合并为单组，这与流变（可能是五聚体）聚合环的存在一致。 197Au Moessbauer 光谱与 Au 与 2 S 配体的线性配位一致，并且与 NMR 数据一致，显示出展宽，表明存在非等价的 Au 原子。这种治疗化合物[用于治疗类风湿性关节炎]在结构上似乎与其他金(I)硫醇盐相似。
A large number of gold(I) thiolates, [AU(SR)], have been prepared in which the R group is an alkyl, aryl, carboxylic acid, amino acid or heterocycle. Most are highly insoluble in all common solvents, but [Au(SC6H4R''-p)] (R'' = Et, Pri, Bus, or But) dissolve in organic solvents. The 1H and 13C NMR spectra of the soluble compounds show several sets of signals, which coalesce to single sets at high temperature, consistent with the presence of fluxional, possibly pentameric, polymeric rings. The 197Au Moessbauer spectra are consistent with linear co-ordination of the Au by 2 S ligands and, in agreement with the NMR data, show broadening indicative of the presence of non-equivalent Au atoms. The therapeutic compounds [used to treat rheumatoid arthritis] appear to be structurally similar to the other gold(I) thiolates.