Quantitative study of follicular development in the ovary of the intact or unilaterally ovariectomized hamster.
Quantitative study of follicular development in the ovary of the intact or unilaterally ovariectomized hamster.
复制标题
完整或单侧卵巢切除仓鼠卵巢卵泡发育的定量研究。
DOI：
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发表时间：
1961
期刊：
影响因子：
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通讯作者：
G. S. Greenwald
中科院分区：
文献类型：
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作者：
G. S. Greenwald
摘要本研究分析了仓鼠发情周期中卵泡数量的变化。将完整动物中的结果与不同时间的半移植动物中的结果进行比较。结果表明，每个卵巢的大卵泡（267µ或更大）的数量在第1天（排卵当天上午9点）基本确定，并维持到周期的第3天。在第3天和第4天之间的卵泡闭锁使每个卵巢的大卵泡数量减少到接近最终排卵的数量。一般来说，任何一只动物的两个卵巢在周期中含有大约相等数量的卵泡。在完整仓鼠月经周期的前3天，一对仓鼠的每个卵巢都含有几乎与最终从两个卵巢排卵的卵泡一样多的大卵泡。在周期的前3天的任何一天切除一个卵巢后，许多卵泡在第4天的卵巢中存留，这些卵泡通常会退化。这表明卵泡闭锁的减少而不是中等大小卵泡增殖的增加是半排卵后代偿性排卵的原因。在第3天单侧卵巢切除术后，下一个周期第1天剩余的卵巢比完整动物或第1天或第4天半切除的仓鼠的第-1天卵巢含有显著更多的卵泡。在发情周期的前3天，在上午9点切除一个卵巢，随后剩余卵巢的排卵数加倍。这些结果与关于卵泡发育的发现一致，表明在下一个发情期排卵的卵泡在周期的第3天确定。
Summary. This study is an analysis of the changes occurring in the population of follicles during the oestrous cycle of the hamster. Findings in the intact animal were compared with those in animals semispayed at various times. The results indicate that the number of large follicles (267µ or greater) is largely determined for each ovary by Day 1 (9 a.m. of the morning of ovulation) and is maintained until the 3rd day of the cycle. Follicular atresia between Days 3 and 4 reduces the number of large follicles per ovary to nearly the number that will eventually ovulate. In general, both ovaries of any one animal contain approximately equal numbers of follicles during the cycle. During the first 3 days of the cycle of the intact hamster, each ovary of a pair contains nearly as many large follicles as will finally ovulate from both ovaries. After the removal of one ovary on any one of the first 3 days of the cycle, numerous follicles persist in the Day-4 ovary that ordinarily would degenerate. This suggests that a decrease in follicular atresia rather than an increase in the proliferation of medium-sized follicles is responsible for compensatory ovulation after semispaying. After unilateral ovariectomy at Day 3, the remaining ovary on the 1st day of the next cycle contains significantly more follicles than the Day-1 ovary of the intact animal or of hamsters that were semispayed on Days 1 or 4. Removal of one ovary at 9 a.m. during the first 3 days of the oestrous cycle was followed by a doubling in the number of ovulations from the remaining ovary. These results agree with the findings on follicular development in indicating that the follicles destined to ovulate at the next oestrus are determined on the 3rd day of the cycle.